Captodiame
http://dbpedia.org/resource/Captodiame an entity of type: Thing
Le captodiame (marque Covatine) est un antihistaminique de la famille des amines et des diphényméthanes dérivée de la diphénhydramine. Ses propriétés anxiolytiques et spasmolytiques le font utiliser pour traiter les troubles psychosomatiques et les effets gênants de l'anxiété. Une étude menée en 2004 suggère que le captodiame pourrait être utile à la prévention du syndrome de sevrage aux benzodiazépines chez les personnes cessant un traitement aux benzodiazépines. Il peut cependant paradoxalement provoquer des insomnies et/ou une somnolence.
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Captodiame (INN), also known as captodiamine, is an antihistamine sold under the trade names Covatine, Covatix, and Suvren which is used as a sedative and anxiolytic. The structure is related to diphenhydramine. A 2004 study suggested captodiame may be helpful in preventing benzodiazepine withdrawal syndrome in people discontinuing benzodiazepine treatment.
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Captodiame
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Captodiame
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Captodiame (INN), also known as captodiamine, is an antihistamine sold under the trade names Covatine, Covatix, and Suvren which is used as a sedative and anxiolytic. The structure is related to diphenhydramine. A 2004 study suggested captodiame may be helpful in preventing benzodiazepine withdrawal syndrome in people discontinuing benzodiazepine treatment. In addition to its actions as an antihistamine, captodiamine has been found to act as a 5-HT2C receptor antagonist and σ1 receptor and D3 receptor agonist. It produces antidepressant-like effects in rats. However, captodiamine is unique among antidepressant-like drugs in that it increases brain-derived neurotrophic factor (BDNF) levels in the hypothalamus but not in the frontal cortex or hippocampus. This unique action may be related to its ability to attenuate stress-induced anhedonia and corticotropin-releasing factor (CRF) signaling in the hypothalamus.
rdf:langString
Le captodiame (marque Covatine) est un antihistaminique de la famille des amines et des diphényméthanes dérivée de la diphénhydramine. Ses propriétés anxiolytiques et spasmolytiques le font utiliser pour traiter les troubles psychosomatiques et les effets gênants de l'anxiété. Une étude menée en 2004 suggère que le captodiame pourrait être utile à la prévention du syndrome de sevrage aux benzodiazépines chez les personnes cessant un traitement aux benzodiazépines. Il peut cependant paradoxalement provoquer des insomnies et/ou une somnolence.
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