Uropod (immunology)

Uropods, in immunology, refer to the hind part of polarized cells during cell migration that stabilize and move the cell. Polarized leukocytes move using amoeboid cell migration mechanisms, with a small leading edge, main cell body, and posterior uropod protrusion. Cytoskeleton contraction and extension, controlled by various polarized signals, helps propel the cell body forward. Leukocyte polarization is an important requirement for migration, activation and apoptosis in the adaptive and innate immune systems; most leukocytes, including monocytes, granulocytes, and T and B lymphocytes migrate to and from primary and secondary lymphoid organs to tissues to initiate immune responses to pathogens. rdf:langString