Tricyanoaminopropene
http://dbpedia.org/resource/Tricyanoaminopropene an entity of type: Thing
El tricianoaminopropeno, conocido también como 1,1,3-triciano-2-amino-1-propeno, 2-amino-1-propeno-1,1,3-tricarbonitrilo, dímero de malononitrilo o TCAP, es un compuesto orgánico de fórmula molecular C6H4N4.Su estructura corresponde a la de un trinitrilo derivado del propeno, estando dos de los tres grupos funcionales -C≡N unidos al carbono 1 del propeno mientras que el tercero lo está al carbono 3; además, tiene un grupo amino (-NH2) unido al carbono 2.
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Tricyanoaminopropene (TRIAP, TCAP, Malononitrile Dimer, 1,1,3-tricyano-2-amino-1-propene) is a nootropic drug which mimics the function of nerve growth factor and increases the growth of nerves and tissue regeneration both in isolated tissues and in vivo. It stimulates the action of the enzyme choline acetyltransferase, resulting in increased acetylcholine production. This then results in increased synthesis of RNA in many different tissues in the body. However it also suppresses the production of thyroxine, causing temporary hypothyroidism which returns to normal once the drug is discontinued.
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Tricianoaminopropeno
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Tricyanoaminopropene
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Investigational
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CCN
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1
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Triap
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El tricianoaminopropeno, conocido también como 1,1,3-triciano-2-amino-1-propeno, 2-amino-1-propeno-1,1,3-tricarbonitrilo, dímero de malononitrilo o TCAP, es un compuesto orgánico de fórmula molecular C6H4N4.Su estructura corresponde a la de un trinitrilo derivado del propeno, estando dos de los tres grupos funcionales -C≡N unidos al carbono 1 del propeno mientras que el tercero lo está al carbono 3; además, tiene un grupo amino (-NH2) unido al carbono 2.
rdf:langString
Tricyanoaminopropene (TRIAP, TCAP, Malononitrile Dimer, 1,1,3-tricyano-2-amino-1-propene) is a nootropic drug which mimics the function of nerve growth factor and increases the growth of nerves and tissue regeneration both in isolated tissues and in vivo. It stimulates the action of the enzyme choline acetyltransferase, resulting in increased acetylcholine production. This then results in increased synthesis of RNA in many different tissues in the body. However it also suppresses the production of thyroxine, causing temporary hypothyroidism which returns to normal once the drug is discontinued. Tricyanoaminopropene reduces the amnesia produced by electroconvulsive shock, and animal tests suggested nootropic activity, but no beneficial effect was found when it was tested in mentally disabled children, and administration to pregnant rats actually reduced learning ability in their young because of its anti-thyroid hormone effects. This drug thus produces two effects which oppose each other, with the nootropic effect from the increased acetylcholine production cancelled out by the opposite effect produced by the decrease in production of thyroxine. It is not known whether the efficacy of the drug could be improved by supplementation with additional thyroxine or equivalent drugs.
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