Tolimidone
http://dbpedia.org/resource/Tolimidone an entity of type: Thing
Tolimidone (CP-26154; MLR-1023) is a compound which was discovered by scientists at Pfizer, was found to stimulate secretion of gastric mucosa, and was in development by Pfizer as a drug candidate to treat gastric ulcers but was abandoned. After the patent on the compound expired, scientists at the company Melior Discovery identified it as a potential drug candidate for diabetes through a phenotypic screen. The company proceeded to show that MLR-1023 is an allosteric activator of Lyn kinase with an EC50 of 63 nM. As of 2012 Melior was repurposing it for diabetes. In June 2016, the company reported positive results from their Phase 2a clinical study in diabetic subjects
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Tolimidona, quimicamente 5-(3-metilfenoxi)pirimidin-2(1H)-ona, é um composto que inibe a secreção ácida em modelos animais e também atua como um broncodilatador em animais afetados pela aplicação de histamina.
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rdf:langString
Tolimidona
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Tolimidone
xsd:integer
27162563
xsd:integer
1076358509
xsd:integer
11
xsd:integer
41964
xsd:integer
8030
xsd:integer
35751
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10
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5
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D06182
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2
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2
xsd:integer
39065
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O=C2/N=C\C=C/N2
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CP-26154, MLR-1023
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MU3JD8E9IS
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Tolimidone (CP-26154; MLR-1023) is a compound which was discovered by scientists at Pfizer, was found to stimulate secretion of gastric mucosa, and was in development by Pfizer as a drug candidate to treat gastric ulcers but was abandoned. After the patent on the compound expired, scientists at the company Melior Discovery identified it as a potential drug candidate for diabetes through a phenotypic screen. The company proceeded to show that MLR-1023 is an allosteric activator of Lyn kinase with an EC50 of 63 nM. As of 2012 Melior was repurposing it for diabetes. In June 2016, the company reported positive results from their Phase 2a clinical study in diabetic subjects
rdf:langString
Tolimidona, quimicamente 5-(3-metilfenoxi)pirimidin-2(1H)-ona, é um composto que inibe a secreção ácida em modelos animais e também atua como um broncodilatador em animais afetados pela aplicação de histamina.
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5093
xsd:string
41964-07-2
xsd:string
8030
xsd:string
MU3JD8E9IS
xsd:string
D06182
xsd:string
39065