Tametraline
http://dbpedia.org/resource/Tametraline an entity of type: Thing
Tametralina (CP-24,441) é um composto químico precursor de uma série de compostos investigados pela Pfizer que, eventualmente, conduziram ao desenvolvimento de sertralina (CP-51,974-1).
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Tametraline (CP-24,441) is the parent of a series of chemical compounds investigated at Pfizer that eventually led to the development of sertraline (CP-51,974-1). Sertraline has been called "3,4-dichloro-tametraline". This is correct but it is an oversimplification in the sense that sertraline is the S,S-isomer whereas tametraline is the 1R,4S-stereoisomer. 1R-Methylamino-4S-phenyl-tetralin is a potent inhibitor of norepinephrine uptake in rat brain synaptosomes, reverses reserpine induced hypothermia in mice, and blocks uptake of 3H-Norepinephrine into rat heart.
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Tametralina
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Tametraline
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HCl
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-N-methyl-4-phenyl-1,2,3,4-tetrahydronaphthalen-1-amine
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CN[C@H]C=C2[C@H]1C3=CC=CC=C3
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Tametraline (CP-24,441) is the parent of a series of chemical compounds investigated at Pfizer that eventually led to the development of sertraline (CP-51,974-1). Sertraline has been called "3,4-dichloro-tametraline". This is correct but it is an oversimplification in the sense that sertraline is the S,S-isomer whereas tametraline is the 1R,4S-stereoisomer. 1R-Methylamino-4S-phenyl-tetralin is a potent inhibitor of norepinephrine uptake in rat brain synaptosomes, reverses reserpine induced hypothermia in mice, and blocks uptake of 3H-Norepinephrine into rat heart. Tametraline is a norepinephrine-dopamine reuptake inhibitor. Indatraline is an indanamine homolog of tetralin-based tametraline, although in the case of indatraline the product is pm-dichlorinated.
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Tametralina (CP-24,441) é um composto químico precursor de uma série de compostos investigados pela Pfizer que, eventualmente, conduziram ao desenvolvimento de sertralina (CP-51,974-1).
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