Salubrinal
http://dbpedia.org/resource/Salubrinal an entity of type: Thing
Salubrinal is a drug which acts as a specific inhibitor of eIF2α phosphatase enzymes and is primarily used experimentally, to study stress responses in eukaryotic cells associated with the action of eIF2. Salubrinal indirectly inhibits eIF2 as a result of reduced dephosphorylation of its α-subunit, resulting in activation of stress response pathways usually triggered by events such as oxidative stress or buildup of unfolded protein in the endoplasmic reticulum. Salubrinal has putative therapeutic value due to its function, but is as yet only used experimentally. Salubrinal is being studied at Indiana University for its potential to fight osteoporosis and accelerate bone healing.
rdf:langString
rdf:langString
Salubrinal
xsd:integer
29066789
xsd:integer
1048281387
xsd:integer
21
xsd:integer
405060
xsd:integer
131923
xsd:integer
180127
xsd:integer
4654442
xsd:integer
3
xsd:integer
17
xsd:integer
3
xsd:integer
4
xsd:integer
1
xsd:integer
5717801
xsd:integer
1
rdf:langString
C1=CC=C/C=C/CNCNCNC2=CC=CC3=C2N=CC=C3
xsd:integer
1
rdf:langString
LCOIAYJMPKXARU-VAWYXSNFSA-N
rdf:langString
changed
xsd:integer
451564438
rdf:langString
changed
rdf:langString
Salubrinal is a drug which acts as a specific inhibitor of eIF2α phosphatase enzymes and is primarily used experimentally, to study stress responses in eukaryotic cells associated with the action of eIF2. Salubrinal indirectly inhibits eIF2 as a result of reduced dephosphorylation of its α-subunit, resulting in activation of stress response pathways usually triggered by events such as oxidative stress or buildup of unfolded protein in the endoplasmic reticulum. Salubrinal has putative therapeutic value due to its function, but is as yet only used experimentally. Salubrinal is being studied at Indiana University for its potential to fight osteoporosis and accelerate bone healing.
xsd:nonNegativeInteger
6369
xsd:string
405060-95-9
xsd:string
131923
xsd:string
180127
xsd:string
5717801