Ro15-4513
http://dbpedia.org/resource/Ro15-4513 an entity of type: Thing
Ro15-4513 (IUPAC: Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate) is a weak partial inverse agonist of the benzodiazepine class of drugs, developed by Hoffmann–La Roche in the 1980s. It acts as a inverse agonist (which acts in a similar way as a competitive antagonist), and can therefore be an antidote to the acute impairment caused by alcohols, including ethanol, isopropanol, tert-butyl alcohol, tert-amyl alcohol, 3-methyl-3-pentanol, methylpentynol and ethchlorvynol. Ro15-4513 is structurally related to the benzodiazepine antidote flumazenil.
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Il Ro15-4513 è uno psicofarmaco appartenente alla categoria delle è un debole agonista parziale inverso, sviluppato da Hoffmann-La Roche negli anni 80'. Agisce come agonista inverso (che agisce in modo analogo come antagonista competitivo), e può quindi essere un antidoto alla compromissione acuta causata da alcol, tra cui etanolo, isopropanolo, alcool terz-butilico, alcool tert-amilico, 3-metil-3-pentanolo, metilpentinolo ed etclorvinolo. Ro15-4513 è strutturalmente correlato al flumazenil.
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Ro15-4513 – organiczny związek chemiczny z grupy benzodiazepin. Nie wykazuje właściwości anksjolitycznych, blokuje miejsce wiązania etanolu na receptorze GABA, cofając w ten sposób narkotyczne działanie alkoholu etylowego. Ze względu na liczne efekty uboczne i krótki okres półtrwania w organizmie nie został wprowadzony na rynek.
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Ro15-4513
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Ro15-4513 (IUPAC: Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate) is a weak partial inverse agonist of the benzodiazepine class of drugs, developed by Hoffmann–La Roche in the 1980s. It acts as a inverse agonist (which acts in a similar way as a competitive antagonist), and can therefore be an antidote to the acute impairment caused by alcohols, including ethanol, isopropanol, tert-butyl alcohol, tert-amyl alcohol, 3-methyl-3-pentanol, methylpentynol and ethchlorvynol. Ro15-4513 is structurally related to the benzodiazepine antidote flumazenil.
rdf:langString
Il Ro15-4513 è uno psicofarmaco appartenente alla categoria delle è un debole agonista parziale inverso, sviluppato da Hoffmann-La Roche negli anni 80'. Agisce come agonista inverso (che agisce in modo analogo come antagonista competitivo), e può quindi essere un antidoto alla compromissione acuta causata da alcol, tra cui etanolo, isopropanolo, alcool terz-butilico, alcool tert-amilico, 3-metil-3-pentanolo, metilpentinolo ed etclorvinolo. Ro15-4513 è strutturalmente correlato al flumazenil.
rdf:langString
Ro15-4513 – organiczny związek chemiczny z grupy benzodiazepin. Nie wykazuje właściwości anksjolitycznych, blokuje miejsce wiązania etanolu na receptorze GABA, cofając w ten sposób narkotyczne działanie alkoholu etylowego. Ze względu na liczne efekty uboczne i krótki okres półtrwania w organizmie nie został wprowadzony na rynek.
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