Ribosome shunting
http://dbpedia.org/resource/Ribosome_shunting an entity of type: Organisation
核糖體分流（Ribosome shunting）為真核生物細胞的核糖體轉譯一些病毒mRNA時，在掃描mRNA的過程中跳過5′非翻译区部分二級結構複雜的序列，直接與該序列下游的序列結合的機制，最早於1990年代在花椰菜嵌紋病毒（CaMV）的mRNA中發現。許多病毒mRNA的核糖體分流需仰賴其5′非翻译区的上游开放阅读框（uORF），核糖體完成uORF的轉譯後（通常僅有2－15個密碼子），60S核糖体亚基自核糖體脫離，40S核糖体亚基則跳過（take-off）mRNA下游5－10nt處一段二級結構複雜的序列，與下游的降落位點（landing site）結合，再重新開始掃描，找到下一個開放閱讀框的起始密碼子後再次與60S亚基結合而開始轉譯。 已知腺病毒、仙台病毒、人類乳突病毒（HPV）、、鴨B型肝炎病毒、（RTBV）與花椰菜嵌紋病毒等多種病毒的mRNA轉譯都有核糖體分流的機制。
rdf:langString
Ribosome shunting is a mechanism of translation initiation in which ribosomes bypass, or "shunt over", parts of the 5' untranslated region to reach the start codon. However, a benefit of ribosomal shunting is that it can translate backwards allowing more information to be stored than usual in an mRNA molecule. Some viral RNAs have been shown to use ribosome shunting as a more efficient form of translation during certain stages of viral life cycle or when translation initiation factors are scarce (e.g. cleavage by viral proteases). Some viruses known to use this mechanism include adenovirus, Sendai virus, human papillomavirus, duck hepatitis B pararetrovirus, rice tungro bacilliform viruses, and cauliflower mosaic virus. In these viruses the ribosome is directly translocated from the upstre
rdf:langString
rdf:langString
Ribosome shunting
rdf:langString
核糖體分流
xsd:integer
3005092
xsd:integer
1123080841
rdf:langString
Ribosome shunting is a mechanism of translation initiation in which ribosomes bypass, or "shunt over", parts of the 5' untranslated region to reach the start codon. However, a benefit of ribosomal shunting is that it can translate backwards allowing more information to be stored than usual in an mRNA molecule. Some viral RNAs have been shown to use ribosome shunting as a more efficient form of translation during certain stages of viral life cycle or when translation initiation factors are scarce (e.g. cleavage by viral proteases). Some viruses known to use this mechanism include adenovirus, Sendai virus, human papillomavirus, duck hepatitis B pararetrovirus, rice tungro bacilliform viruses, and cauliflower mosaic virus. In these viruses the ribosome is directly translocated from the upstream initiation complex to the start codon (AUG) without the need to unwind RNA secondary structures.
rdf:langString
核糖體分流（Ribosome shunting）為真核生物細胞的核糖體轉譯一些病毒mRNA時，在掃描mRNA的過程中跳過5′非翻译区部分二級結構複雜的序列，直接與該序列下游的序列結合的機制，最早於1990年代在花椰菜嵌紋病毒（CaMV）的mRNA中發現。許多病毒mRNA的核糖體分流需仰賴其5′非翻译区的上游开放阅读框（uORF），核糖體完成uORF的轉譯後（通常僅有2－15個密碼子），60S核糖体亚基自核糖體脫離，40S核糖体亚基則跳過（take-off）mRNA下游5－10nt處一段二級結構複雜的序列，與下游的降落位點（landing site）結合，再重新開始掃描，找到下一個開放閱讀框的起始密碼子後再次與60S亚基結合而開始轉譯。 已知腺病毒、仙台病毒、人類乳突病毒（HPV）、、鴨B型肝炎病毒、（RTBV）與花椰菜嵌紋病毒等多種病毒的mRNA轉譯都有核糖體分流的機制。
xsd:nonNegativeInteger
10018