Rho-associated protein kinase
http://dbpedia.org/resource/Rho-associated_protein_kinase an entity of type: Thing
Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine specific protein kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton. Protein kinase C and Rho-associated protein kinase are involved in regulating calcium ion intake; these calcium ions, in turn stimulate a myosin light chain kinase, forcing a contraction. Rho-associated protein kinase are serine or threonine kinases that determine the calcium sensitivity in smooth muscle cells.
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La proteina chinasi associata a Rho (Rho-associated protein kinase, ROCK) è una chinasi che appartiene alla famiglia AGC (PKA/PKG/PKC) delle serina-treonina chinasi. È coinvolta principalmente nella regolazione della forma e del movimento delle cellule agendo sul loro citoscheletro. Le chinasi ROCKs (ROCK1 and ROCK2) sono presenti nei:
* mammiferi (umano, ratto, topo, mucca);
* danio rerio (pesce zebra);
* xenopus;
* invertebrati (C. elegans, mosquito, drosophila);
* polli. La proteina ROCK dei mammiferi è composta da:
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Proteina chinasi associata a Rho
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Rho-associated protein kinase
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Rho-associated, coiled-coil-containing protein kinase 1
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Rho-associated, coiled-coil-containing protein kinase 2
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ROCK
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Rho-associated, coiled-coil-containing protein kinase 1
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Crystal structure of human ROCK I
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Rho-associated protein kinase
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O75116
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Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine specific protein kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton. ROCKs (ROCK1 and ROCK2) occur in mammals (human, rat, mouse, cow), zebrafish, Xenopus, invertebrates (C. elegans, mosquito, Drosophila) and chicken. Human ROCK1 has a molecular mass of 158 kDa and is a major downstream effector of the small GTPase RhoA. Mammalian ROCK consists of a kinase domain, a coiled-coil region and a Pleckstrin homology (PH) domain, which reduces the kinase activity of ROCKs by an autoinhibitory intramolecular fold if RhoA-GTP is not present. Rat ROCKs were discovered as the first effectors of Rho and they induce the formation of stress fibers and focal adhesions by phosphorylating MLC (myosin light chain).Due to this phosphorylation, the actin binding of myosin II and, thus, the contractility increases. Two mouse ROCK isoforms ROCK1 and ROCK2 have been identified. ROCK1 is mainly expressed in the lung, liver, spleen, kidney and testis. However, ROCK2 is distributed mostly in the brain and heart. Protein kinase C and Rho-associated protein kinase are involved in regulating calcium ion intake; these calcium ions, in turn stimulate a myosin light chain kinase, forcing a contraction. Rho-associated protein kinase are serine or threonine kinases that determine the calcium sensitivity in smooth muscle cells.
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La proteina chinasi associata a Rho (Rho-associated protein kinase, ROCK) è una chinasi che appartiene alla famiglia AGC (PKA/PKG/PKC) delle serina-treonina chinasi. È coinvolta principalmente nella regolazione della forma e del movimento delle cellule agendo sul loro citoscheletro. Le chinasi ROCKs (ROCK1 and ROCK2) sono presenti nei:
* mammiferi (umano, ratto, topo, mucca);
* danio rerio (pesce zebra);
* xenopus;
* invertebrati (C. elegans, mosquito, drosophila);
* polli. La proteina umana ROCK1 ha una massa molecolare di 158 kDa ed è il principale effettore a valle a seguito dell'azione della piccola GTPasi RhoA. La proteina ROCK dei mammiferi è composta da: 1.
* un dominio chinasico; 2.
* una regione coiled-coil; 3.
* un dominio PH (Pleckstrin homology) che riduce l'attività chinasica delle ROCKs (per mezzo di una piega intramolecolare autoinibitoria se non è presente RhoA-GTP). Nel ratto Le ROCKs furono scoperte come i primi effettori di Rho; esse inducono la formazione delle stress fibers e delle fosforilando la MLC (myosin light chain, catena leggera della miosina). A causa di questa fosforilazione, il legame dell'actina alla miosina II aumenta in numero: pertanto aumenta la contrattilità. Nel topo sono state identificate due isoforme di ROCK: ROCK1 e ROCK2. ROCK1 è espressa principalmente nei polmoni, fegato, milza, reni e testicolo; ROCK2 è espressa prevalentemente nel cervello e nel cuore.
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Rho-associated protein kinase
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Rho-associated, coiled-coil-containing protein kinase
