Rabacfosadine

http://dbpedia.org/resource/Rabacfosadine an entity of type: Thing

Rabacfosadine, sold under the brand name Tanovea-CA1, is a guanine nucleotide analog used for the treatment of lymphoma in dogs. The drug was granted conditional approval by the U.S. Food and Drug Administration under application number 141-475 for use in treating canine lymphoma in December 2016 pending a full demonstration of effectiveness, and became the first drug to receive full approval for the treatment of canine lymphoma in July 2021. Originally developed by Gilead Sciences as GS-9219, rabacfosadine is no longer being pursued for use in the treatment of lymphoma in humans. rdf:langString
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rdf:langString Rabacfosadine, sold under the brand name Tanovea-CA1, is a guanine nucleotide analog used for the treatment of lymphoma in dogs. The drug was granted conditional approval by the U.S. Food and Drug Administration under application number 141-475 for use in treating canine lymphoma in December 2016 pending a full demonstration of effectiveness, and became the first drug to receive full approval for the treatment of canine lymphoma in July 2021. Originally developed by Gilead Sciences as GS-9219, rabacfosadine is no longer being pursued for use in the treatment of lymphoma in humans. The active form of rabacfosadine is a chain-terminating inhibitor of the major deoxyribonucleic acid (DNA) polymerases. In vitro studies have demonstrated that rabacfosadine inhibits DNA synthesis, resulting in S phase arrest and induction of apoptosis. It also inhibits the proliferation of lymphocytes in dogs with naturally occurring lymphoma.
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