Protocadherin
http://dbpedia.org/resource/Protocadherin an entity of type: Thing
Les protocadhérines (PCDH) font partie des différentes variations de cadhérines séquencées par l'Homme. Il y a environ 60 PCDH différentes. Elles interviennent dans le système nerveux central ainsi qu'au niveau du guidage axonal (PCDH10) permettant l'homéostasie et la morphogénèse.
* Portail de la biologie cellulaire et moléculaire
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Protocadherins (Pcdhs) are the largest mammalian subgroup of the cadherin superfamily of homophilic cell-adhesion proteins. They were discovered by Shintaro Suzuki's group, when they used PCR to find new members of the cadherin family. The PCR fragments that corresponded to protocadherins were found in vertebrate and invertebrate species. This prevalence in a wide range of species suggested that the fragments were part of an ancient cadherin and were thus termed "Protocadherins" as the "first cadherins". Of the approximately 70 Pcdh genes identified in mammalian genomes, over 50 are located in tightly linked gene clusters on the same chromosome. Until recently, it was assumed that this kind of organization can only be found in vertebrates, but Octopus bimaculoides has 168 genes of which ne
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Protocadhérine
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Protocadherin
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Protocadherin, cytoplasmic
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9919262
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1090980570
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Domain organization of different types of cadherins showing unique features of protocadherins: Extracellular domain is longer and intracellular domain lacks attachment with cytoskeleton.
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IPR013585
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PF08374
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PDCH
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300
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Les protocadhérines (PCDH) font partie des différentes variations de cadhérines séquencées par l'Homme. Il y a environ 60 PCDH différentes. Elles interviennent dans le système nerveux central ainsi qu'au niveau du guidage axonal (PCDH10) permettant l'homéostasie et la morphogénèse.
* Portail de la biologie cellulaire et moléculaire
rdf:langString
Protocadherins (Pcdhs) are the largest mammalian subgroup of the cadherin superfamily of homophilic cell-adhesion proteins. They were discovered by Shintaro Suzuki's group, when they used PCR to find new members of the cadherin family. The PCR fragments that corresponded to protocadherins were found in vertebrate and invertebrate species. This prevalence in a wide range of species suggested that the fragments were part of an ancient cadherin and were thus termed "Protocadherins" as the "first cadherins". Of the approximately 70 Pcdh genes identified in mammalian genomes, over 50 are located in tightly linked gene clusters on the same chromosome. Until recently, it was assumed that this kind of organization can only be found in vertebrates, but Octopus bimaculoides has 168 genes of which nearly three-quarters are found in tandem clusters with the two largest clusters compromising 31 and 17 genes, respectively.
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114
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16205
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PDCH