Protein-S-isoprenylcysteine O-methyltransferase
http://dbpedia.org/resource/Protein-S-isoprenylcysteine_O-methyltransferase an entity of type: Thing
La proteina-S-isoprenilcisteina O-metiltransferasi è un enzima appartenente alla classe delle transferasi, che catalizza la seguente reazione: S-adenosil-L-metionina + C-terminale di una proteina S-farnesil-L-cisteina ⇄ S-adenosil-L-omocisteina + S-farnesil-L-cisteina metil estere sul C-terminale della proteina Anche il C-terminale dei residui di S-geranilgeranilcisteina e di S-geranilcisteina viene metilato, ma più lentamente.
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The isoprenylcysteine o-methyltransferase (EC 2.1.1.100) carries out carboyxl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae (Baker's yeast) this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology. The enzyme catalyzes the chemical reaction
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Proteina-S-isoprenilcisteina O-metiltransferasi
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Protein-S-isoprenylcysteine O-methyltransferase
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ICMT
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protein-S-isoprenylcysteine O-methyltransferase
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14025208
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1044423740
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130731
xsd:double
2.1
xsd:integer
4671
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IPR007269
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2
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PF04140
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CL0115
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ICMT
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The isoprenylcysteine o-methyltransferase (EC 2.1.1.100) carries out carboyxl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae (Baker's yeast) this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology. The enzyme catalyzes the chemical reaction S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester Thus, the two substrates of this enzyme are S-adenosyl methionine and protein C-terminal S-farnesyl-L-cysteine, whereas its two products are S-adenosylhomocysteine and protein C-terminal S-farnesyl-L-cysteine methyl ester.
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La proteina-S-isoprenilcisteina O-metiltransferasi è un enzima appartenente alla classe delle transferasi, che catalizza la seguente reazione: S-adenosil-L-metionina + C-terminale di una proteina S-farnesil-L-cisteina ⇄ S-adenosil-L-omocisteina + S-farnesil-L-cisteina metil estere sul C-terminale della proteina Anche il C-terminale dei residui di S-geranilgeranilcisteina e di S-geranilcisteina viene metilato, ma più lentamente.
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159
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4
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3469
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ICMT