Phosphoinositide phospholipase C
http://dbpedia.org/resource/Phosphoinositide_phospholipase_C an entity of type: Thing
Phosphoinositide phospholipase C (PLC, EC 3.1.4.11, triphosphoinositide phosphodiesterase, phosphoinositidase C, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, PI-PLC, 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase; systematic name 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase) is a family of eukaryotic intracellular enzymes that play an important role in signal transduction processes. These enzymes belong to a larger superfamily of Phospholipase C. Other families of phospholipase C enzymes have been identified in bacteria and trypanosomes. Phospholipases C are phosphodiesterases.
rdf:langString
rdf:langString
Phosphoinositide phospholipase C
rdf:langString
Phosphatidylinositol-specific phospholipase C
rdf:langString
PI-PLC-Y
rdf:langString
phosphoinositide phospholipase C
xsd:integer
3233543
xsd:integer
1106590664
rdf:langString
PDOC50007
xsd:integer
1
rdf:langString
PLCXc
rdf:langString
PLCYc
xsd:integer
1
rdf:langString
activated rac1 bound to its effector phospholipase c beta 2
rdf:langString
Phospholipase Cδ-1
xsd:integer
37213
xsd:double
3.1
xsd:integer
4435
rdf:langString
IPR000909
rdf:langString
IPR001711
xsd:integer
3
rdf:langString
PF00387
rdf:langString
PF00388
rdf:langString
CL0384
rdf:langString
PI-PLC-X
rdf:langString
PI-PLC-Y
xsd:integer
220
270
rdf:langString
Phosphoinositide phospholipase C (PLC, EC 3.1.4.11, triphosphoinositide phosphodiesterase, phosphoinositidase C, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, PI-PLC, 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase; systematic name 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase) is a family of eukaryotic intracellular enzymes that play an important role in signal transduction processes. These enzymes belong to a larger superfamily of Phospholipase C. Other families of phospholipase C enzymes have been identified in bacteria and trypanosomes. Phospholipases C are phosphodiesterases. Phospholipase Cs participate in phosphatidylinositol 4,5-bisphosphate (PIP2) metabolism and lipid signaling pathways in a calcium-dependent manner. At present, the family consists of six sub-families comprising a total of 13 separate isoforms that differ in their mode of activation, expression levels, catalytic regulation, cellular localization, membrane binding avidity and tissue distribution. All are capable of catalyzing the hydrolysis of PIP2 into two important second messenger molecules, which go on to alter cell responses such as proliferation, differentiation, apoptosis, cytoskeleton remodeling, vesicular trafficking, ion channel conductance, endocrine function and neurotransmission.
rdf:langString
cd00137
xsd:integer
118
126
xsd:integer
1
2
xsd:nonNegativeInteger
18759
xsd:string
PI-PLC-X
PI-PLC-Y
