Paraoxonase

http://dbpedia.org/resource/Paraoxonase an entity of type: Thing

对氧磷酶（英語：Paraoxonase，PON）是一種蛋白質，目前有三種，分別是、與，此三者皆是人類基因，三者皆位於7號染色體上。它是一種高密度脂蛋白所運送的水解酵素，最早被發現可以分解巴拉松（Paraoxon），故稱為「巴拉松酶」（Paraoxonase）。近期的研究認為屏氧酶與冠心病的發生發展密切相關。 rdf:langString

Paraoxonases are a family of mammalian enzymes with aryldialkylphosphatase activity. There are three paraoxonase isozymes, which were originally discovered for their involvement in the hydrolysis of organophosphates. rdf:langString

rdfs:label

rdf:langString Paraoxonase

rdf:langString 对氧磷酶

foaf:name

rdf:langString paraoxonase 1

rdf:langString paraoxonase 2

rdf:langString paraoxonase 3

dbpedia-owl:wikiPageID

xsd:integer 17211110

dbpedia-owl:wikiPageRevisionID

xsd:integer 994190855

dbpprop:omim

xsd:integer 168820 602447 602720

dbpprop:altsymbols

rdf:langString PON

dbpprop:ecnumber

xsd:double 3.1

dbpprop:uniprot

rdf:langString P27169

rdf:langString Q15165

rdf:langString Q15166

dbpedia-owl:abstract

rdf:langString Paraoxonases are a family of mammalian enzymes with aryldialkylphosphatase activity. There are three paraoxonase isozymes, which were originally discovered for their involvement in the hydrolysis of organophosphates. Research has indicated the enzymatic activity of paraoxonases is more diversified than its activity as an organophosphatase. Esterase and lactonase activity has also been observed from these enzymes and though the physiologically relevant substrates for these enzymes are unknown, it is likely that lactones are the main substrate (although there is a relatively high level of variation in substrate specificity among these enzymes). Most of the studies on the paraoxonase family have specifically looked at the paraoxonase 1 type, leaving much to be learned about the remaining two. The study of this enzyme family has many potential consequences in preventative medicine and toxicology as well as in certain societal contexts. The genes that encode for these enzymes have a number of different polymorphisms, which created additional interest in the study of this enzyme group and its potential ethnic variations. Additional research on the inhibition and selective inhibition, specifically of PON1, has been done to shed some light on the connections between decreases in enzymatic activity of individuals with cardiovascular diseases. Evidence also suggests that this family of enzymes has some role in our innate immune system.

rdf:langString 对氧磷酶（英語：Paraoxonase，PON）是一種蛋白質，目前有三種，分別是、與，此三者皆是人類基因，三者皆位於7號染色體上。它是一種高密度脂蛋白所運送的水解酵素，最早被發現可以分解巴拉松（Paraoxon），故稱為「巴拉松酶」（Paraoxonase）。近期的研究認為屏氧酶與冠心病的發生發展密切相關。

dbpprop:arm

rdf:langString q

dbpprop:band

xsd:double 21.3

dbpprop:chromosome

xsd:integer 7

dbpprop:entrezgene

xsd:integer 5444 5445 5446

dbpprop:hgncid

xsd:integer 9204 9205 9206

dbpprop:refseq

rdf:langString NM_000305