PEST sequence

http://dbpedia.org/resource/PEST_sequence an entity of type: Abstraction100002137

PEST-Sequenzen sind Teile von Proteinen, die besonders reich an den Aminosäuren Prolin (P), Glutamat (E), Serin (S) und Threonin (T) sind, welches zu einer geringeren Halbwertszeit t1/2 des gesamten Proteins führt und damit zu einem schnelleren Abbau im Proteasom. Sie sind unter anderem enthalten in Androgen-, Estrogen- und Vitamin-D-Rezeptoren. Die Aktivität von PEST-Sequenzen wird durch Phosphorylierung benachbarter Domänen reguliert. rdf:langString
Una secuencia PEST es una secuencia peptídica rica en residuos de prolina (P), ácido glutámico (E), serina (S), y treonina (T). Dicha secuencia se asocia con proteínas que tienen una vida media celular corta; de ahí que se hipotetice que la secuencia PEST actúa como péptido señal para degradación proteolítica.​ Dicha degradación puede estar mediada, posiblemente, por el proteasoma​​ o por calpaína.​ rdf:langString
A PEST sequence is a peptide sequence that is rich in proline (P), glutamic acid (E), serine (S), and threonine (T). This sequence is associated with proteins that have a short intracellular half-life; therefore, it is hypothesized that the PEST sequence acts as a signal peptide for protein degradation. This protein degradation may be mediated via the proteasome or calpain. Other signals thought to identify proteins for degradation include cyclin destruction boxes, which are amino acid sequences that mark cell-cycle proteins for destruction. rdf:langString
rdf:langString PEST-Sequenz
rdf:langString Secuencia PEST
rdf:langString PEST sequence
xsd:integer 11827758
xsd:integer 1122556325
rdf:langString PEST-Sequenzen sind Teile von Proteinen, die besonders reich an den Aminosäuren Prolin (P), Glutamat (E), Serin (S) und Threonin (T) sind, welches zu einer geringeren Halbwertszeit t1/2 des gesamten Proteins führt und damit zu einem schnelleren Abbau im Proteasom. Sie sind unter anderem enthalten in Androgen-, Estrogen- und Vitamin-D-Rezeptoren. Die Aktivität von PEST-Sequenzen wird durch Phosphorylierung benachbarter Domänen reguliert.
rdf:langString Una secuencia PEST es una secuencia peptídica rica en residuos de prolina (P), ácido glutámico (E), serina (S), y treonina (T). Dicha secuencia se asocia con proteínas que tienen una vida media celular corta; de ahí que se hipotetice que la secuencia PEST actúa como péptido señal para degradación proteolítica.​ Dicha degradación puede estar mediada, posiblemente, por el proteasoma​​ o por calpaína.​
rdf:langString A PEST sequence is a peptide sequence that is rich in proline (P), glutamic acid (E), serine (S), and threonine (T). This sequence is associated with proteins that have a short intracellular half-life; therefore, it is hypothesized that the PEST sequence acts as a signal peptide for protein degradation. This protein degradation may be mediated via the proteasome or calpain. Other signals thought to identify proteins for degradation include cyclin destruction boxes, which are amino acid sequences that mark cell-cycle proteins for destruction.
xsd:nonNegativeInteger 2115

data from the linked data cloud