Olsalazine
http://dbpedia.org/resource/Olsalazine an entity of type: Thing
أولسالازين Olsalazine هو أولسالازين الصوديوم.
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Olsalazine is an anti-inflammatory medication used in the treatment of ulcerative colitis. It is sold under the brand name Dipentum. Olsalazine itself is a pro-drug of mesalazine (5-aminosalicyclic acid or 5-ASA) and is not absorbed in the small intestine. Instead it continues through to the colon where it is cleaved into two molecules of 5-ASA by azoreductases produced by colonic bacteria. Olsalazine thus exerts its anti-inflammatory effect by its colonic breakdown into 5-ASA which inhibits cyclooxygenase and lipoxygenase thereby reducing prostaglandin and leukotriene production.
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L'olsalazina è un farmaco antinfiammatorio non steroideo appartenente alla classe dei salicilati e usato nel trattamento delle malattie infiammatorie croniche intestinali come la rettocolite ulcerosa. Come per la balsalazide si ritiene che sia un profarmaco la cui forma attiva è costituita dalla mesalazina ovvero l'acido 5-amminosalicilico (5-ASA) cui viene trasformata selettivamente nel colon, essendo pertanto utile nel trattamento della colite ulcerosa.
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أولسالازين
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Olsalazina
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Olsalazine
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DB01250
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as salt
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D00727
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D08295
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POM
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Rx-only
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a601088
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C
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O=Cc1cc/N=N/c2ccccc2
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Dipentum
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ULS5I8J03O
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changed
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أولسالازين Olsalazine هو أولسالازين الصوديوم.
rdf:langString
Olsalazine is an anti-inflammatory medication used in the treatment of ulcerative colitis. It is sold under the brand name Dipentum. Olsalazine itself is a pro-drug of mesalazine (5-aminosalicyclic acid or 5-ASA) and is not absorbed in the small intestine. Instead it continues through to the colon where it is cleaved into two molecules of 5-ASA by azoreductases produced by colonic bacteria. Olsalazine thus exerts its anti-inflammatory effect by its colonic breakdown into 5-ASA which inhibits cyclooxygenase and lipoxygenase thereby reducing prostaglandin and leukotriene production.
rdf:langString
L'olsalazina è un farmaco antinfiammatorio non steroideo appartenente alla classe dei salicilati e usato nel trattamento delle malattie infiammatorie croniche intestinali come la rettocolite ulcerosa. Come per la balsalazide si ritiene che sia un profarmaco la cui forma attiva è costituita dalla mesalazina ovvero l'acido 5-amminosalicilico (5-ASA) cui viene trasformata selettivamente nel colon, essendo pertanto utile nel trattamento della colite ulcerosa.
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Olsalazine
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Dipentum
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D00727
D08295
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a601088
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