Nisoxetine
http://dbpedia.org/resource/Nisoxetine an entity of type: Thing
Nisoxetin (LY-94939) ist ein Selektiver Noradrenalin-Wiederaufnahmehemmer (NARI). Ursprünglich wurde es als Antidepressivum entwickelt, kam aber nicht über die Entwicklungsstufe hinaus. Es gilt allerdings in der wissenschaftlichen Forschung als „Standard-NARI“ und wird als solches häufig verwendet. Es wird als Racemat eingesetzt.
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니속세틴(Nisoxetine, LY-94939)은 노르에피네프린의 재흡수를 억제하는 약이다. 이성질체와 함께 라세믹 혼합물이다. 최근에는 니속세틴을 사람에게 투여하지 않으나, NRI 원래 우울증 치료제로서 연구와 현재 NRL 선별 기준으로서의 과학 연구에 널리 사용된다.
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Nisoxetine, originally synthesized in the Lilly research laboratories during the early 1970s, is a potent and selective inhibitor for the reuptake of norepinephrine (noradrenaline) into synapses. It currently has no clinical applications in humans, although it was originally researched as an antidepressant. Nisoxetine is now widely used in scientific research as a standard selective norepinephrine reuptake inhibitor. It has been used to research obesity and energy balance, and exerts some local analgesia effects.
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Nisoxetin
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니속세틴
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Nisoxetine
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16454909
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1107676221
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None
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17
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53179
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73410
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295467
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4344
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21
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-3
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D05173
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Never marketed
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4500
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CNCCCOC2=CC=CC=C2OC
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1
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ITJNARMNRKSWTA-UHFFFAOYSA-N
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-γ--N-methyl-benzenepropanamine hydrochloride
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LY-94939,
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17
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changed
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492910405
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changed
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175
rdf:langString
Nisoxetin (LY-94939) ist ein Selektiver Noradrenalin-Wiederaufnahmehemmer (NARI). Ursprünglich wurde es als Antidepressivum entwickelt, kam aber nicht über die Entwicklungsstufe hinaus. Es gilt allerdings in der wissenschaftlichen Forschung als „Standard-NARI“ und wird als solches häufig verwendet. Es wird als Racemat eingesetzt.
rdf:langString
Nisoxetine, originally synthesized in the Lilly research laboratories during the early 1970s, is a potent and selective inhibitor for the reuptake of norepinephrine (noradrenaline) into synapses. It currently has no clinical applications in humans, although it was originally researched as an antidepressant. Nisoxetine is now widely used in scientific research as a standard selective norepinephrine reuptake inhibitor. It has been used to research obesity and energy balance, and exerts some local analgesia effects. Researchers have attempted to use a carbon-labeled form of nisoxetine for positron emission tomography (PET) imaging of the norepinephrine transporter (NET), with little success. However, it seems that tritium labeled nisoxetine (3H-nisoxetine, 3H-NIS) is a useful radioligand for labeling norepinephrine uptake sites in vitro, which nisoxetine and other antagonists for NET are able to inhibit.
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니속세틴(Nisoxetine, LY-94939)은 노르에피네프린의 재흡수를 억제하는 약이다. 이성질체와 함께 라세믹 혼합물이다. 최근에는 니속세틴을 사람에게 투여하지 않으나, NRI 원래 우울증 치료제로서 연구와 현재 NRL 선별 기준으로서의 과학 연구에 널리 사용된다.
xsd:integer
4637
xsd:nonNegativeInteger
24615
xsd:string
53179-07-0
xsd:string
73410
xsd:string
295467
xsd:string
17NV064B2D
xsd:string
D05173
xsd:string
4500