Nimetazepam

http://dbpedia.org/resource/Nimetazepam an entity of type: Thing

Le nimétazépam est une benzodiazépine développée dans les années 1960. Il n'est pas commercialisé en France. rdf:langString

Il nimetazepam (venduto sotto i nomi commerciali Erimin e Lavol) è uno psicofarmaco appartenente alla categoria delle benzodiazepine, sintetizzato per la prima volta dalla casa farmaceutica Hoffmann-La Roche nel 1964. Il farmaco è un analogo del nitrazepam, con l'unica differenza della presenza di un gruppo metilico. È usato come anticonvulsivante e come ipnotico per la gestione a breve termine dell'insonnia. È commercializzato, soprattutto nei paesi asiatici in compresse da 5 mg note come Erimin, che è il marchio prodotto e commercializzato dalla grande società giapponese Sumitomo. rdf:langString

ニメタゼパム (nimetazepam) は、ベンゾジアゼピン系の睡眠導入剤の一種。中時間作用型。日本では、1977年より商品名エリミンとして大日本住友製薬から発売され、適応は不眠症。このエリミンは、2015年8月在庫品の出荷をもって販売中止された。連用により依存症、急激な量の減少により離脱症状を生じることがある。向精神薬に関する条約のスケジュールIVに指定されている。麻薬及び向精神薬取締法の第三種向精神薬である。 rdf:langString

Nimetazepam – organiczny związek chemiczny, lek z grupy benzodiazepin. Jest objęty Konwencją o substancjach psychotropowych z 1971 roku (wykaz IV). W Polsce jest w grupie IV-P Ustawy o przeciwdziałaniu narkomanii. rdf:langString

Nimetazepam, summaformel C16H13N3O3, är ett ångestdämpande och lugnande preparat som tillhör gruppen bensodiazepiner. Ämnet patenterades 1964 av läkemedelsföretaget Hoffman-La Roche. Substansen är narkotikaklassad och ingår i förteckning P IV i 1971 års psykotropkonvention, samt i förteckning IV i Sverige. rdf:langString

硝甲西泮（Nimetazepam），又译硝甲氮平，其作用為中樞神經抑制劑。俗称一粒眠（Erimine），属中华民国三級管制性藥品，又稱「紅豆」、「五仔」、「K它命5號」、「Give me Five」。 rdf:langString

Nimetazepam ist ein Hypnotikum aus der Gruppe der Benzodiazepine. Es ist das N-methylierte Derivat von Nitrazepam und wurde 1962 von Hoffmann-La Roche entwickelt. Es besitzt amnestische, anxiolytische, antikonvulsive, hypnotische, sedative und muskelrelaxierende Potenziale. Es wird zur kurzfristigen Behandlung schwerer Schlafstörungen eingesetzt. Nimetazepam wurde 1978 von Sumitomo Dainippon Pharma unter dem Handelsnamen Erimin auf den japanischen Markt gebracht. Die Substanz ist in Deutschland nicht erhältlich.(Siehe auch: Missbrauch von Benzodiazepinen) rdf:langString

Nimetazepam (marketed under brand name Erimin and Lavol) is an intermediate-acting hypnotic drug which is a benzodiazepine derivative. It was first synthesized by a team at Hoffmann-La Roche in 1964. It possesses powerful hypnotic, anxiolytic, sedative, and skeletal muscle relaxant properties. Nimetazepam is also a particularly potent anticonvulsant. It is marketed in 5 mg tablets known as Erimin, which is the brand name manufactured and marketed by the large Japanese corporation Sumitomo. Japan is the sole manufacturer of nimetazepam in the world. Outside of Japan, Erimin is available in much of East and Southeast Asia and was widely prescribed for the short-term treatment of severe insomnia in patients who have difficulty falling asleep or maintaining sleep. Sumitomo has ceased manufactu rdf:langString

O nimetazepam (comercializado sob a marca Erimin e Lavol) é um hipnótico de ação intermediária derivado da benzodiazepina. Foi sintetizado pela primeira vez por uma equipe da Hoffmann-La Roche em 1962. Possui propriedades hipnóticas, ansiolíticas, sedativas e relaxantes musculoesqueléticas. O nimetazepam também é um anticonvulsivante. É vendido em comprimidos de 5mg sob os nomes comerciais Erimin e Lavol. Geralmente é prescrito para o tratamento de curto prazo de insônia grave em pacientes que têm dificuldade em adormecer ou manter o sono. O único fabricante global de Nimetazepam (Sumitomo) parou de fabricar Erimin desde o início de novembro de 2015. Os pacientes que recebem prescrição de Erimin estão sendo transferidos para Lavol e outros hipnóticos, por exemplo, estazolam, nitrazepam, fl rdf:langString

rdfs:label

rdf:langString Nimetazepam

rdf:langString Nimétazépam

rdf:langString Nimetazepam

rdf:langString ニメタゼパム

rdf:langString Nimetazepam

rdf:langString 硝甲西泮

dbpedia-owl:wikiPageID

xsd:integer 4119926

dbpedia-owl:wikiPageRevisionID

xsd:integer 1091019843

dbpprop:atcSuffix

rdf:langString CD15

dbpprop:atcPrefix

rdf:langString N05

dbpprop:bioavailability

<perCent> 95.0

dbpprop:c

xsd:integer 16

dbpprop:casNumber

xsd:integer 2011

dbpprop:chebi

xsd:integer 31912

dbpprop:chembl

xsd:integer 13341

dbpprop:chemspiderid

xsd:integer 4340

dbpprop:eliminationHalfLife

<second> -108000.0

dbpprop:h

xsd:integer 13

dbpprop:image

rdf:langString Nimetazepam ball-and-stick model.png

dbpprop:iupacName

xsd:integer 1

dbpprop:kegg

rdf:langString D01593

dbpprop:legalDe

rdf:langString Anlage III

dbpprop:legalUs

rdf:langString Schedule IV

dbpprop:n

xsd:integer 3

dbpprop:o

xsd:integer 3

dbpprop:pregnancyCategory

rdf:langString X

dbpprop:pubchem

xsd:integer 4496

dbpprop:smiles

rdf:langString [O-][N+]=O

dbpprop:stdinchi

xsd:integer 1

dbpprop:stdinchikey

rdf:langString GWUSZQUVEVMBPI-UHFFFAOYSA-N

dbpprop:tradename

rdf:langString Erimin

dbpprop:unii

xsd:integer 4532264

dbpprop:verifiedfields

rdf:langString changed

dbpprop:verifiedrevid

xsd:integer 464372782

dbpprop:watchedfields

rdf:langString changed

dbpprop:width

xsd:integer 200 222

dbpedia-owl:abstract

rdf:langString Nimetazepam ist ein Hypnotikum aus der Gruppe der Benzodiazepine. Es ist das N-methylierte Derivat von Nitrazepam und wurde 1962 von Hoffmann-La Roche entwickelt. Es besitzt amnestische, anxiolytische, antikonvulsive, hypnotische, sedative und muskelrelaxierende Potenziale. Es wird zur kurzfristigen Behandlung schwerer Schlafstörungen eingesetzt. Nimetazepam wurde 1978 von Sumitomo Dainippon Pharma unter dem Handelsnamen Erimin auf den japanischen Markt gebracht. Die Substanz ist in Deutschland nicht erhältlich. Nimetazepam gehört zu den mittellangwirksamen Benzodiazepinen mit einer Eliminationshalbwertszeit von 14 bis 30 Stunden. Die Bioverfügbarkeit bei oraler Einnahme beträgt nahezu 100 % und es zeichnet sich durch den schnellsten Wirkeintritt aller oralen Benzodiazepine aus. Die Äquivalenzdosis zu 10 mg Diazepam beträgt 10 mg Nimetazepam.Nimetazepam weist wie alle Hypnotika aus der Benzodiazepin-Klasse ein hohes Abhängigkeits- und Missbrauchspotenzial auf. Durch den besonders schnellen Wirkungseintritt jedoch, ist das Missbrauchspotential bei diesem speziellen Benzodiazepin besonders hoch.(Siehe auch: Missbrauch von Benzodiazepinen)

rdf:langString Le nimétazépam est une benzodiazépine développée dans les années 1960. Il n'est pas commercialisé en France.

rdf:langString Nimetazepam (marketed under brand name Erimin and Lavol) is an intermediate-acting hypnotic drug which is a benzodiazepine derivative. It was first synthesized by a team at Hoffmann-La Roche in 1964. It possesses powerful hypnotic, anxiolytic, sedative, and skeletal muscle relaxant properties. Nimetazepam is also a particularly potent anticonvulsant. It is marketed in 5 mg tablets known as Erimin, which is the brand name manufactured and marketed by the large Japanese corporation Sumitomo. Japan is the sole manufacturer of nimetazepam in the world. Outside of Japan, Erimin is available in much of East and Southeast Asia and was widely prescribed for the short-term treatment of severe insomnia in patients who have difficulty falling asleep or maintaining sleep. Sumitomo has ceased manufacturing Erimin since November 2015. It is still available as a generic drug or as Lavol. Nimetazepam was widely prescribed in the 1980s and 1990s, particularly in Japan, Malaysia, Brunei, the Philippines, Thailand, Indonesia, Hong Kong and Singapore. Prescriptions for the drug have decreased dramatically since 2005 due to rampant misuse and addiction. It is primarily used as an anticonvulsant in children. It is also still used in the most severe and debilitating cases of insomnia in an inpatient setting or in short term outpatient treatment. Hypnotic benzodiazepines estazolam and nitrazepam are used more frequently than nimetazepam for this purpose. Antidepressants such as trazodone and mirtazapine or Z-drugs like zopiclone and zolpidem are first line treatment for insomnia. Although prescriptions for nimetazepam have decreased, abuse of the drug is still significant in Brunei, Singapore, Malaysia, and the Philippines. It is commonly used in combination with methamphetamine and MDMA (Ecstasy) and opiates (especially heroin or morphine). The strict legal restrictions nimetazepam is subject to in Malaysia has made the drug scarce, but many pills sold as nimetazepam in the black market are counterfeit. Diazepam and nitrazepam are among the most commonly prescribed benzodiazepines in the region, and as a result, they are commonly diverted and sold on the black market, often as nimetazepam. Illicit manufacturing of nimetazepam (sold as Erimin-5) is prevalent in the region. Abuse of nimetazepam continued to rise throughout the 2010s. Seizures of illicitly manufactured Erimin-5 tablets paralleled the seizures of methamphetamine seizures in Malaysia. A small seizure of 46 illicit Erimin-5 tablets were tested for their physical and chemical characteristics. The active ingredient, adulterant, major diluent, and dyes make up the chemical characteristics of a tablet. The results indicated that nimetazepam was the most common active ingredient in the vast majority of the tablets seized. Lactose was detected as a major diluent in the majority of the samples, followed by mannitol and then calcium phosphate dibasic dihydrate. Sunset yellow was found in most of the tablet samples either alone or in combination with other dyes such as tartrazine and ponceau 4R to give the tablets a peach/orange colour. Green tablets in the samples contained brilliant blue and tartrazine dyes. Diazepam, which is primarily an anxiolytic, was the active ingredient in only one tablet out of the 46. Nitrazepam, a powerful sedative-hypnotic, which is also nimetazepams parent drug, was found to be a minor compound together with a caffeine as a major compound in three of the tablets. In 2003, 94,200 Erimin-5 tablets were seized in Singapore. The Central Narcotics Bureau's (CNB) laboratory tested the tablets with results that confirmed the tablets were indeed nimetazepam.

rdf:langString Il nimetazepam (venduto sotto i nomi commerciali Erimin e Lavol) è uno psicofarmaco appartenente alla categoria delle benzodiazepine, sintetizzato per la prima volta dalla casa farmaceutica Hoffmann-La Roche nel 1964. Il farmaco è un analogo del nitrazepam, con l'unica differenza della presenza di un gruppo metilico. È usato come anticonvulsivante e come ipnotico per la gestione a breve termine dell'insonnia. È commercializzato, soprattutto nei paesi asiatici in compresse da 5 mg note come Erimin, che è il marchio prodotto e commercializzato dalla grande società giapponese Sumitomo.

rdf:langString ニメタゼパム (nimetazepam) は、ベンゾジアゼピン系の睡眠導入剤の一種。中時間作用型。日本では、1977年より商品名エリミンとして大日本住友製薬から発売され、適応は不眠症。このエリミンは、2015年8月在庫品の出荷をもって販売中止された。連用により依存症、急激な量の減少により離脱症状を生じることがある。向精神薬に関する条約のスケジュールIVに指定されている。麻薬及び向精神薬取締法の第三種向精神薬である。

rdf:langString Nimetazepam – organiczny związek chemiczny, lek z grupy benzodiazepin. Jest objęty Konwencją o substancjach psychotropowych z 1971 roku (wykaz IV). W Polsce jest w grupie IV-P Ustawy o przeciwdziałaniu narkomanii.

rdf:langString O nimetazepam (comercializado sob a marca Erimin e Lavol) é um hipnótico de ação intermediária derivado da benzodiazepina. Foi sintetizado pela primeira vez por uma equipe da Hoffmann-La Roche em 1962. Possui propriedades hipnóticas, ansiolíticas, sedativas e relaxantes musculoesqueléticas. O nimetazepam também é um anticonvulsivante. É vendido em comprimidos de 5mg sob os nomes comerciais Erimin e Lavol. Geralmente é prescrito para o tratamento de curto prazo de insônia grave em pacientes que têm dificuldade em adormecer ou manter o sono. O único fabricante global de Nimetazepam (Sumitomo) parou de fabricar Erimin desde o início de novembro de 2015. Os pacientes que recebem prescrição de Erimin estão sendo transferidos para Lavol e outros hipnóticos, por exemplo, estazolam, nitrazepam, flunitrazepam, etc.

rdf:langString Nimetazepam, summaformel C16H13N3O3, är ett ångestdämpande och lugnande preparat som tillhör gruppen bensodiazepiner. Ämnet patenterades 1964 av läkemedelsföretaget Hoffman-La Roche. Substansen är narkotikaklassad och ingår i förteckning P IV i 1971 års psykotropkonvention, samt i förteckning IV i Sverige.

rdf:langString 硝甲西泮（Nimetazepam），又译硝甲氮平，其作用為中樞神經抑制劑。俗称一粒眠（Erimine），属中华民国三級管制性藥品，又稱「紅豆」、「五仔」、「K它命5號」、「Give me Five」。

dbpprop:legalAu

rdf:langString S4

dbpprop:legalCa

rdf:langString Schedule IV

dbpprop:legalUn

rdf:langString Psychotropic Schedule IV

dbpedia-owl:bioavailability

xsd:float 95.0

dbpedia-owl:wikiPageLength

xsd:nonNegativeInteger 15597

dbpedia-owl:alternativeName