Messenger RNA decapping
http://dbpedia.org/resource/Messenger_RNA_decapping
Dekaping mRNA – proces hydrolizy mostka fosforanowego w strukturze czapeczki mRNA, stanowiący kluczowy etap regulacji stabilności i translacji mRNA.
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mRNA去帽（mRNA decapping）又稱mRNA脫帽，是細胞中將mRNA的5′端帽水解還原成5′磷酸基的反應。真核生物細胞中正活躍轉譯的mRNA會與多核糖體結合，5′端帽會與eIF4E、eIF4G等起始因子結合而難與去帽酶接觸，在養分缺乏或受病毒感染等逆境中mRNA的轉譯可能被抑制，使5′端帽裸露，等去帽酶可將其5′端帽移除，之後mRNA的5′磷酸基會被RNA外切酶等識別，使mRNA被快速降解 。去帽與mRNA降解可能皆是在處理小體（P-body）中進行。原核生物中也有類似機制，mRNA的5′端帽則可被等去帽酶水解，將三磷酸基轉為單磷酸基，促進RNA被降解。 真核生物中具無義突變的mRNA轉譯時會觸發无义介导的mRNA降解（NMD）途徑，將mRNA去帽後降解。一些miRNA也可促進去帽酶與其目標的mRNA結合，進而將其去帽降解。
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The process of messenger RNA decapping consists of hydrolysis of the 5' cap structure on the RNA exposing a 5' monophosphate. In eukaryotes, this 5' monophosphate is a substrate for the 5' exonuclease Xrn1 and the mRNA is quickly destroyed. There are many situations which may lead to the removal of the cap, some of which are discussed below.
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Messenger RNA decapping
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Dekaping mRNA
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MRNA去帽
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1043421545
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The process of messenger RNA decapping consists of hydrolysis of the 5' cap structure on the RNA exposing a 5' monophosphate. In eukaryotes, this 5' monophosphate is a substrate for the 5' exonuclease Xrn1 and the mRNA is quickly destroyed. There are many situations which may lead to the removal of the cap, some of which are discussed below. In prokaryotes, the initial mRNA transcript naturally possesses a 5'-triphosphate group after bacterial transcription; the enzyme RppH removes a pyrophosphate molecule from the 5' end, converting the 5'-triphosphate to a 5'-monophosphate, triggering mRNA degradation by ribonucleases.
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Dekaping mRNA – proces hydrolizy mostka fosforanowego w strukturze czapeczki mRNA, stanowiący kluczowy etap regulacji stabilności i translacji mRNA.
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mRNA去帽（mRNA decapping）又稱mRNA脫帽，是細胞中將mRNA的5′端帽水解還原成5′磷酸基的反應。真核生物細胞中正活躍轉譯的mRNA會與多核糖體結合，5′端帽會與eIF4E、eIF4G等起始因子結合而難與去帽酶接觸，在養分缺乏或受病毒感染等逆境中mRNA的轉譯可能被抑制，使5′端帽裸露，等去帽酶可將其5′端帽移除，之後mRNA的5′磷酸基會被RNA外切酶等識別，使mRNA被快速降解 。去帽與mRNA降解可能皆是在處理小體（P-body）中進行。原核生物中也有類似機制，mRNA的5′端帽則可被等去帽酶水解，將三磷酸基轉為單磷酸基，促進RNA被降解。 真核生物中具無義突變的mRNA轉譯時會觸發无义介导的mRNA降解（NMD）途徑，將mRNA去帽後降解。一些miRNA也可促進去帽酶與其目標的mRNA結合，進而將其去帽降解。
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4111
