Melatonin receptor

http://dbpedia.org/resource/Melatonin_receptor an entity of type: Thing

Un receptor de melatonina es un receptor acoplado a proteína G (GPCR) cuyo ligando es la melatonina. Se han clonado tres tipos de receptores de melatonina. El MT1 (o Mel1A o MTNR1A) el MT2 (o Mel1B o MTNR1B) están presentes en humanos y otros mamíferos, mientras que el subtipo adicional (o MTNR1C) se ha identificado en anfibios, aves y peces rdf:langString

Os receptores de melatonina são uma classe de receptores acoplados à proteína G que tem a melatonina como ligante endógeno. rdf:langString

Melatonin receptors are G protein-coupled receptors (GPCR) which bind melatonin. Three types of melatonin receptors have been cloned. The MT1 (or Mel1A or MTNR1A) and MT2 (or Mel1B or MTNR1B) receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype MT3 (or Mel1C or MTNR1C) has been identified in amphibia and birds. The receptors are crucial in the signal cascade of melatonin. In the field of chronobiology, melatonin has been found to be a key player in the synchrony of biological clocks. Melatonin secretion by the pineal gland has circadian rhythmicity regulated by the suprachiasmatic nucleus (SCN) found in the brain. The SCN functions as the timing regulator for melatonin; melatonin then follows a feedback loop to decrease SCN neuronal firi rdf:langString

rdfs:label

rdf:langString Receptor de melatonina

rdf:langString Melatonin receptor

rdf:langString Receptor de melatonina

foaf:name

rdf:langString melatonin receptor 1A

rdf:langString melatonin receptor 1B

dbpedia-owl:wikiPageID

xsd:integer 8258942

dbpedia-owl:wikiPageRevisionID

xsd:integer 1116751551

dbpprop:omim

xsd:integer 600665 600804

dbpprop:symbol

rdf:langString MTNR1A

rdf:langString MTNR1B

dbpprop:uniprot

rdf:langString P48039

rdf:langString P49286

dbpedia-owl:abstract

rdf:langString Un receptor de melatonina es un receptor acoplado a proteína G (GPCR) cuyo ligando es la melatonina. Se han clonado tres tipos de receptores de melatonina. El MT1 (o Mel1A o MTNR1A) el MT2 (o Mel1B o MTNR1B) están presentes en humanos y otros mamíferos, mientras que el subtipo adicional (o MTNR1C) se ha identificado en anfibios, aves y peces

rdf:langString Melatonin receptors are G protein-coupled receptors (GPCR) which bind melatonin. Three types of melatonin receptors have been cloned. The MT1 (or Mel1A or MTNR1A) and MT2 (or Mel1B or MTNR1B) receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype MT3 (or Mel1C or MTNR1C) has been identified in amphibia and birds. The receptors are crucial in the signal cascade of melatonin. In the field of chronobiology, melatonin has been found to be a key player in the synchrony of biological clocks. Melatonin secretion by the pineal gland has circadian rhythmicity regulated by the suprachiasmatic nucleus (SCN) found in the brain. The SCN functions as the timing regulator for melatonin; melatonin then follows a feedback loop to decrease SCN neuronal firing. The receptors MT1 and MT2 control this process. Melatonin receptors are found throughout the body in places such as the brain, the retina of the eye, the cardiovascular system, the liver and gallbladder, the colon, the skin, the kidneys, and many others. In 2019, X-ray crystal and cryo-EM structures of MT1 and MT2 were reported.

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