MTORC2

http://dbpedia.org/resource/MTORC2 an entity of type: Thing

mTORC2 (mTOR complex 2) je proteinový komplex tvořený serin/threoninovou kinázou mTOR. Je necitlivý vůči účinkům a reguluje buněčnou proliferaci, migraci a remodelaci cytoskeletu. Samotný komplex se skládá ze sedmi proteinových podjednotek. Katalytickou mTOR podjednotku, (DEP domain containing mTOR-interacting protein), (mammalian lethal with sec-13 protein 8, někdy také známou pod názvem ) a komplex lze nalézt jak u mTORC2, tak u . (Rapamycin-insensitive companion of mTOR), (mammalian stress-activated protein kinase interacting protein 1) a (protein observed with rictor 1 and 2) jsou pak pouze součástí mTORC2. Vazba substrátu na mTORC2 je zprostředkována přes Rictor. rdf:langString

mTOR Complex 2 (mTORC2) is an acutely rapamycin-insensitive protein complex formed by serine/threonine kinase mTOR that regulates cell proliferation and survival, cell migration and cytoskeletal remodeling. The complex itself is rather large, consisting of seven protein subunits. The catalytic mTOR subunit, DEP domain containing mTOR-interacting protein (DEPTOR), mammalian lethal with sec-13 protein 8 (mLST8, also known as GβL), and TTI1/TEL2 complex are shared by both mTORC2 and mTORC1. Rapamycin-insensitive companion of mTOR (RICTOR), mammalian stress-activated protein kinase interacting protein 1 (mSIN1), and protein observed with rictor 1 and 2 (/2) can only be found in mTORC2. Rictor has been shown to be the scaffold protein for substrate binding to mTORC2. rdf:langString

rdfs:label

rdf:langString MTORC2

foaf:name

rdf:langString MAPKAP1

rdf:langString MLST8

rdf:langString RICTOR

rdf:langString mTOR

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rdf:langString FRAP, FRAP2, FRAP1

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rdf:langString P42345

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dbpedia-owl:abstract

rdf:langString mTORC2 (mTOR complex 2) je proteinový komplex tvořený serin/threoninovou kinázou mTOR. Je necitlivý vůči účinkům a reguluje buněčnou proliferaci, migraci a remodelaci cytoskeletu. Samotný komplex se skládá ze sedmi proteinových podjednotek. Katalytickou mTOR podjednotku, (DEP domain containing mTOR-interacting protein), (mammalian lethal with sec-13 protein 8, někdy také známou pod názvem ) a komplex lze nalézt jak u mTORC2, tak u . (Rapamycin-insensitive companion of mTOR), (mammalian stress-activated protein kinase interacting protein 1) a (protein observed with rictor 1 and 2) jsou pak pouze součástí mTORC2. Vazba substrátu na mTORC2 je zprostředkována přes Rictor.

rdf:langString mTOR Complex 2 (mTORC2) is an acutely rapamycin-insensitive protein complex formed by serine/threonine kinase mTOR that regulates cell proliferation and survival, cell migration and cytoskeletal remodeling. The complex itself is rather large, consisting of seven protein subunits. The catalytic mTOR subunit, DEP domain containing mTOR-interacting protein (DEPTOR), mammalian lethal with sec-13 protein 8 (mLST8, also known as GβL), and TTI1/TEL2 complex are shared by both mTORC2 and mTORC1. Rapamycin-insensitive companion of mTOR (RICTOR), mammalian stress-activated protein kinase interacting protein 1 (mSIN1), and protein observed with rictor 1 and 2 (/2) can only be found in mTORC2. Rictor has been shown to be the scaffold protein for substrate binding to mTORC2.

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