Lymphotoxin

http://dbpedia.org/resource/Lymphotoxin an entity of type: Thing

Lymphotoxin-α (kurz LTA, alternativ auch Tumornekrosefaktor-β, kurz TNFB, oder ganz wissenschaftlich Tumor necrosis factor ligand superfamily member 1, kurz TNFSF1) ist ein Zytokin aus der TNF/TNFR-Superfamilie. Es hat viele Gemeinsamkeiten mit TNF – teilt z. B. dessen Rezeptoren – wird aber von aktivierten Lymphozyten sezerniert. Es ist wie TNF ein Modulator der Immunantwort. Mutationen im LTA-Gen sind mit altersabhängiger Lepra und mit Psoriasis-Arthritis assoziiert. rdf:langString

Linfotoxina (también conocida como Factor de necrosis tumoral beta, FNT - β o factor citotóxico) es una linfocina citoquina. rdf:langString

( 종양 괴사 인자 알파에 대해서는 종양 괴사 인자 알파 문서를 참고하십시오.) 림프독소(lymphotoxin)은 과거에 종양 괴사 인자 베타(Tumor necrosis factor-beta, TNF-β)라고 불렸던 림포카인의 일종인 시토카인이다. 이들은 Th1 타입의 T 세포에 의해 생성되는 단백질로, 혈관의 내피세포가 대식세포들이 달라붙을 수 있도록 표면 부착 분자를 바꾸게 유도한다. 이들은 또한 파이어 판의 정상적인 분화를 위해 필요한 것으로 알려져 있다. 림프독소는 종양 괴사 인자 베타와 동일하지만, T 세포에 의해서 분비된다. 이것은 적은 양 생성되기 때문에 측분비이다.이것의 효과는 TNF-alpha와 비슷하지만, TNF-beta는 또한 림프성 기관의 발달에 중요하다. rdf:langString

淋巴毒素（lymphotoxin）属一员，是一种肿瘤坏死因子類细胞因子，由产生，可诱导血管内皮细胞表面黏附分子的改變，並促進吞噬细胞与之结合。淋巴毒素分为淋巴毒素-α（LT-α）及淋巴毒素-β（LT-β），前者旧称“肿瘤坏死因子-β”。 rdf:langString

Lymphotoxin is a member of the tumor necrosis factor (TNF) superfamily of cytokines, whose members are responsible for regulating the growth and function of lymphocytes and are expressed by a wide variety of cells in the body. rdf:langString

Tumornecrosefactor bèta TNF-β, ook wel bekend als lymfotoxine, is een van de twee tumornecrosefactoren en daarmee een cytokine. De andere tumornecrosefactor is tumornecrosefactor α TNFα. Het is een eiwit dat wordt gemaakt door cytotoxische T-cellen van het immuunsysteem die viraal geïnfecteerde cellen ombrengen. Het gen voor TNF-β ligt op chromosoom 6 van het humane genoom. TNF-β wordt geproduceerd als oplosbaar polypeptide en kan heterotrimeren vormen met de lymfotoxine-bètareceptor die TNF-β aan het celoppervlak kan binden. TNF-β is cytotoxisch voor een breed spectrum van tumorcellen. rdf:langString

rdfs:label

rdf:langString Lymphotoxin-α

rdf:langString Linfotoxina

rdf:langString Lymphotoxin

rdf:langString 림프독소

rdf:langString Tumornecrosefactor β

rdf:langString 淋巴毒素

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rdf:langString lymphotoxin alpha (TNF superfamily, member 1)

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rdf:langString TNFB

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rdf:langString Lymphotoxin-α (kurz LTA, alternativ auch Tumornekrosefaktor-β, kurz TNFB, oder ganz wissenschaftlich Tumor necrosis factor ligand superfamily member 1, kurz TNFSF1) ist ein Zytokin aus der TNF/TNFR-Superfamilie. Es hat viele Gemeinsamkeiten mit TNF – teilt z. B. dessen Rezeptoren – wird aber von aktivierten Lymphozyten sezerniert. Es ist wie TNF ein Modulator der Immunantwort. Mutationen im LTA-Gen sind mit altersabhängiger Lepra und mit Psoriasis-Arthritis assoziiert.

rdf:langString Lymphotoxin is a member of the tumor necrosis factor (TNF) superfamily of cytokines, whose members are responsible for regulating the growth and function of lymphocytes and are expressed by a wide variety of cells in the body. Lymphotoxin plays a critical role in developing and preserving the framework of lymphoid organs and of gastrointestinal immune responses, as well as in the activation signaling of both the innate and adaptive immune responses. Lymphotoxin alpha (LT-α, previously known as TNF-beta) and lymphotoxin beta (LT-β), the two forms of lymphotoxin, each have distinctive structural characteristics and perform specific functions.

rdf:langString Linfotoxina (también conocida como Factor de necrosis tumoral beta, FNT - β o factor citotóxico) es una linfocina citoquina.

rdf:langString ( 종양 괴사 인자 알파에 대해서는 종양 괴사 인자 알파 문서를 참고하십시오.) 림프독소(lymphotoxin)은 과거에 종양 괴사 인자 베타(Tumor necrosis factor-beta, TNF-β)라고 불렸던 림포카인의 일종인 시토카인이다. 이들은 Th1 타입의 T 세포에 의해 생성되는 단백질로, 혈관의 내피세포가 대식세포들이 달라붙을 수 있도록 표면 부착 분자를 바꾸게 유도한다. 이들은 또한 파이어 판의 정상적인 분화를 위해 필요한 것으로 알려져 있다. 림프독소는 종양 괴사 인자 베타와 동일하지만, T 세포에 의해서 분비된다. 이것은 적은 양 생성되기 때문에 측분비이다.이것의 효과는 TNF-alpha와 비슷하지만, TNF-beta는 또한 림프성 기관의 발달에 중요하다.

rdf:langString Tumornecrosefactor bèta TNF-β, ook wel bekend als lymfotoxine, is een van de twee tumornecrosefactoren en daarmee een cytokine. De andere tumornecrosefactor is tumornecrosefactor α TNFα. Het is een eiwit dat wordt gemaakt door cytotoxische T-cellen van het immuunsysteem die viraal geïnfecteerde cellen ombrengen. Het gen voor TNF-β ligt op chromosoom 6 van het humane genoom. TNF-β behoort tot de TNF-familie van liganden voor de receptoren TNFR1 en TNFR2. TNF-β wordt geproduceerd door zowel geactiveerde T- als B-cellen en heeft een vergelijkbare functie als TNF-alfa. TNF-β speelt een rol bij verschillende biologische processen waaronder proliferatie van B- en T-cellen, apoptose, vetmetabolisme en neurotransmissie. TNF-β wordt geproduceerd als oplosbaar polypeptide en kan heterotrimeren vormen met de lymfotoxine-bètareceptor die TNF-β aan het celoppervlak kan binden. TNF-β is cytotoxisch voor een breed spectrum van tumorcellen.

rdf:langString 淋巴毒素（lymphotoxin）属一员，是一种肿瘤坏死因子類细胞因子，由产生，可诱导血管内皮细胞表面黏附分子的改變，並促進吞噬细胞与之结合。淋巴毒素分为淋巴毒素-α（LT-α）及淋巴毒素-β（LT-β），前者旧称“肿瘤坏死因子-β”。

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