Levuglandin
http://dbpedia.org/resource/Levuglandin an entity of type: Thing
Levuglandins are reactive aldehydes formed by the spontaneous rearrangement of prostaglandin H (PGH). Enantiomerically pure levuglandin (LG) E2 can also be formed through the cyclooxygenase (COX) pathway by a rearrangement of the prostaglandin (PG) endoperoxide PGH 2. They are nonclassic eicosanoids. One species, levuglandin E2, (LGE2), forms neurotoxic adducts with amyloid beta.Levuglandins and isolevuglandins can damage proteins by covalent adduction, thereby interfering with their normal functions. These lipid-derived protein modifications may serve as dosimeters of oxidative injury. Elevated plasma levels of isoLG-protein epitopes are associated with atherosclerosis but are independent of total cholesterol, a classical risk factor.
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Le levuglandine, o levuloglandine, sono eicosanoidi derivati dall'acido arachidonico. Si formano spontaneamente nell'organismo in seguito al riarrangiamento delle prostaglandine tramite condensazione aldolica.
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Levuglandine
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Levuglandin
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Levuglandin D2
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Levuglandin E2
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Levuglandin D2
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Levuglandin E2
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1042992987
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Levuglandin D2.svg
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Levuglandin E2.svg
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-9
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LGE2
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changed
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367263100
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Levuglandins are reactive aldehydes formed by the spontaneous rearrangement of prostaglandin H (PGH). Enantiomerically pure levuglandin (LG) E2 can also be formed through the cyclooxygenase (COX) pathway by a rearrangement of the prostaglandin (PG) endoperoxide PGH 2. They are nonclassic eicosanoids. One species, levuglandin E2, (LGE2), forms neurotoxic adducts with amyloid beta.Levuglandins and isolevuglandins can damage proteins by covalent adduction, thereby interfering with their normal functions. These lipid-derived protein modifications may serve as dosimeters of oxidative injury. Elevated plasma levels of isoLG-protein epitopes are associated with atherosclerosis but are independent of total cholesterol, a classical risk factor.
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Le levuglandine, o levuloglandine, sono eicosanoidi derivati dall'acido arachidonico. Si formano spontaneamente nell'organismo in seguito al riarrangiamento delle prostaglandine tramite condensazione aldolica.
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LGE2
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(5Z,8R,9R,10E,12S)-8-acetyl-9-formyl-12- hydroxyheptadeca-5,10-dienoic acid
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(5Z,8R,9R,10E,12S)-9-acetyl-8-formyl-12- hydroxyheptadeca-5,10-dienoic acid