Leucine rich repeat containing 15

rdf:langString Leucine rich repeat containing 15

rdf:langString Leucine rich repeat containing 15 is a cell membrane expressed protein that in humans is encoded by the LRRC15 gene. located on chromosome 3 at 3q29 that belongs to the LRR superfamily, which is involved in cell–cell and cell–ECM interactions. There is preliminary evidence that expression may be related to the severity of COVID-19 and that it is an inhibitory accessory factor for SARS-CoV-2 entry to cells. LRRC15 lacks obvious intracellular domains. LRRC15 displays a highly restricted expression pattern, but is expressed in areas that make up innate immune barriers such as the placenta, skin, activated fibroblasts in wounds, and lymphoid tissues such as the spleen. LRRC15 may play some role in innate immunity. LRRC15 is aberrantly expressed in cancer. It is highly expressed in CAFs within the stroma of numerous solid tumors and directly expressed in mesenchymal tumors such as glioblastoma, sarcomas, and melanoma.