Hepatitis C virus internal ribosome entry site

rdf:langString Hepatitis C virus internal ribosome entry site

rdf:langString Hepatitis C virus internal ribosome entry site

rdf:langString Viruses

rdf:langString HCV_IRES

rdf:langString Predicted secondary structure and sequence conservation of IRES_HCV

rdf:langString RF00061

rdf:langString IRES_HCV

rdf:langString The Hepatitis C virus internal ribosome entry site, or HCV IRES, is an RNA structure within the 5'UTR of the HCV genome that mediates cap-independent translation initiation. Protein translation of most eukaryotic mRNAs occurs by a cap-dependent mechanism and requires association of Met-tRNAiMet, several eukaryotic initiation factors, and GTP with the 40S ribosomal subunit, recruitment to the 5' cap, and scanning along the 5' UTR to reach to start codon. In contrast, translation of hepatitis C virus (HCV) mRNA is initiated by a different mechanism from the usual 5' cap-binding model. This alternate mechanism relies on the direct binding of the 40S ribosomal subunit by the internal ribosome entry site (IRES) in the 5' UTR of HCV RNA. The HCV IRES adopts a complex structure, and may differ significantly from IRES elements identified in picornaviruses. A small number of eukaryotic mRNA have been shown to be translated by internal ribosome entry.

rdf:langString RF00061