Glycylpeptide N-tetradecanoyltransferase
http://dbpedia.org/resource/Glycylpeptide_N-tetradecanoyltransferase an entity of type: Thing
La glicilpeptide N-tetradecanoiltransferasi è un enzima appartenente alla classe delle transferasi, che catalizza la seguente reazione: tetra + glicilpeptide ⇄ CoA + N-tetradecanoilglicilpeptide L'enzima del lievito è altamente specifico per il tetradecanoil-CoA, ed anche per la glicina N-terminale negli oligopeptidi contenenti serina alla posizione 5. L'enzima del cuore dei mammiferi trasferisce gruppi acilici ad una specifica proteina accettore di 51 kDa.
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In enzymology, a glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97) is an enzyme that catalyzes the chemical reaction tetradecanoyl-CoA + glycylpeptide CoA + N-tetradecanoylglycylpeptide Thus, the two substrates of this enzyme are and , whereas its two products are CoA and . It participates in the N-Myristoylation of proteins, and in vertebrates there are two isoenzymes NMT1 and NMT2.
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Glycylpeptide N-tetradecanoyltransferase
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Glicilpeptide N-tetradecanoiltransferasi
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glycylpeptide N-tetradecanoyltransferase
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NMT, C-terminal
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NMT, N-terminal
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glycylpeptide N-tetradecanoyltransferase
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14543210
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989205542
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3
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Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA. Myristoyl-CoA . PDB ID: 3IU1
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110071
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2.3
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4379
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IPR022677
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IPR022676
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2
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PF02799
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PF01233
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NMT_C
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NMT
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In enzymology, a glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97) is an enzyme that catalyzes the chemical reaction tetradecanoyl-CoA + glycylpeptide CoA + N-tetradecanoylglycylpeptide Thus, the two substrates of this enzyme are and , whereas its two products are CoA and . It participates in the N-Myristoylation of proteins, and in vertebrates there are two isoenzymes NMT1 and NMT2. Besides tetradecanoyl-CoA, this enzyme is also capable of using modified versions of this substrate. In human retina, an even wider range of fatty acids, including 14:1 n–9, 14:2n–6, and 12:0, are accepted by the enzyme and grafted onto guanylate cyclase activators. This is mainly a result of a special set of fatty-acid-CoA substrates available in the retina.
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La glicilpeptide N-tetradecanoiltransferasi è un enzima appartenente alla classe delle transferasi, che catalizza la seguente reazione: tetra + glicilpeptide ⇄ CoA + N-tetradecanoilglicilpeptide L'enzima del lievito è altamente specifico per il tetradecanoil-CoA, ed anche per la glicina N-terminale negli oligopeptidi contenenti serina alla posizione 5. L'enzima del cuore dei mammiferi trasferisce gruppi acilici ad una specifica proteina accettore di 51 kDa.
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3
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4223
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2.3.1.97