Estradiol benzoate cyclooctenyl ether
http://dbpedia.org/resource/Estradiol_benzoate_cyclooctenyl_ether an entity of type: Thing
Estradiol benzoate cyclooctenyl ether (EBCO), or estradiol 3-benzoate 17β-cyclooctenyl ether, is a synthetic estrogen as well as estrogen ester and ether – specifically, the C3 benzoate ester and C17β cyclooctenyl ether of estradiol – which was described in the early 1970s and was never marketed. It has been found to have a dramatically prolonged duration of action with oral administration in animals, similarly to the related compound quinestrol (the 3-cyclopentyl ether of ethinylestradiol). A single oral dose of EBCO sustained high uterus weights for 3 weeks in rats. This long-lasting activity may be due to storage of EBCO in fat. It appears that EBCO is absorbed satisfactorily from the gastrointestinal tract, at least partially survives first-pass metabolism in the liver and intestines,
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rdf:langString
Estradiol benzoate cyclooctenyl ether
rdf:langString
EBCO
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57753344
xsd:integer
1120785526
xsd:integer
33
xsd:integer
28200
xsd:integer
4940765
rdf:langString
EBCO
xsd:integer
40
rdf:langString
[-17-[-cycloocten-1-yl]oxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] benzoate
xsd:integer
3
xsd:integer
6436089
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C[C@]12CC[C@H]3[C@H]CCC5=C3C=CCOCC6=CC=CC=C6
xsd:integer
1
rdf:langString
DOFNLZKUGHVIMH-UQWKGHMASA-N
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EBCO; Estradiol 3-benzoate 17β-cyclooctenyl ether
xsd:integer
250
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Estradiol benzoate cyclooctenyl ether (EBCO), or estradiol 3-benzoate 17β-cyclooctenyl ether, is a synthetic estrogen as well as estrogen ester and ether – specifically, the C3 benzoate ester and C17β cyclooctenyl ether of estradiol – which was described in the early 1970s and was never marketed. It has been found to have a dramatically prolonged duration of action with oral administration in animals, similarly to the related compound quinestrol (the 3-cyclopentyl ether of ethinylestradiol). A single oral dose of EBCO sustained high uterus weights for 3 weeks in rats. This long-lasting activity may be due to storage of EBCO in fat. It appears that EBCO is absorbed satisfactorily from the gastrointestinal tract, at least partially survives first-pass metabolism in the liver and intestines, and is then sequestered into fat, from which it is slowly released and activated into estradiol. In contrast to quinestrol, the oral activity of EBCO is greatly improved when it is delivered in an oil solution as opposed to an aqueous vehicle.
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5509
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28200-94-4
xsd:string
6436089