Epipregnanolone
http://dbpedia.org/resource/Epipregnanolone an entity of type: Thing
表孕烷醇酮（英語：Epipregnanolone，暨3β-羟基-5β-孕烷-20-酮，3β-hydroxy-5β-pregnan-20-one，也被称为3β,5β-四氢孕酮，3β,5β-tetrahydroprogesterone，3β,5β-THP）是一种内源性，是GABAA受体的负向，可逆转别孕烷醇酮等正向别构调节剂的作用。 表孕烷醇酮本身并不是孕激素，但可以代谢为其它孕烷衍生物而有孕激素功能。
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Epipregnanolone, also known as 3β-hydroxy-5β-pregnan-20-one, 3β,5β-tetrahydroprogesterone, or 3β,5β-THP, is an endogenous neurosteroid. It acts as a negative allosteric modulator of the GABAA receptor and reverses the effects of potentiators like allopregnanolone. Epipregnanolone is biosynthesized from progesterone by the actions of 5β-reductase and 3β-hydroxysteroid dehydrogenase, with 5β-dihydroprogesterone as the intermediate in this two-step transformation. Epipregnanolone is not a progestogen itself, but via metabolization into other steroids, behaves indirectly as one.
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Epipregnanolone
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表孕烷醇酮
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Epipregnanolone.svg
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Epipregnanolone, also known as 3β-hydroxy-5β-pregnan-20-one, 3β,5β-tetrahydroprogesterone, or 3β,5β-THP, is an endogenous neurosteroid. It acts as a negative allosteric modulator of the GABAA receptor and reverses the effects of potentiators like allopregnanolone. Epipregnanolone is biosynthesized from progesterone by the actions of 5β-reductase and 3β-hydroxysteroid dehydrogenase, with 5β-dihydroprogesterone as the intermediate in this two-step transformation. Epipregnanolone is not a progestogen itself, but via metabolization into other steroids, behaves indirectly as one. The sulfate of epipreganolone, , is a negative allosteric modulator of the NMDA and GABAA receptors and also acts as a TRPM3 channel activator.
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表孕烷醇酮（英語：Epipregnanolone，暨3β-羟基-5β-孕烷-20-酮，3β-hydroxy-5β-pregnan-20-one，也被称为3β,5β-四氢孕酮，3β,5β-tetrahydroprogesterone，3β,5β-THP）是一种内源性，是GABAA受体的负向，可逆转别孕烷醇酮等正向别构调节剂的作用。 表孕烷醇酮本身并不是孕激素，但可以代谢为其它孕烷衍生物而有孕激素功能。
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3β,5β-Tetrahydroprogesterone
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3β-Hydoxy-5β-pregnan-20-one
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1-[(1S,3aS,3bR,5aR,7S,9aS,9bS,11aS)-7-Hydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]ethan-1-one