Epileptogenesis

rdf:langString Epileptogenesis

rdf:langString Epileptogenesis is the gradual process by which a typical brain develops epilepsy. Epilepsy is a chronic condition in which seizures occur. These changes to the brain occasionally cause neurons to fire in an abnormal, hypersynchronous manner, known as a seizure. Epileptogenesis is a chronic disorder. Genetic factors are the most triggering factor. The treatment is difficult to find. There is almost no therapy available for epileptogenesis patients. In epileptogenesis, a normal brain is transformed into an epileptic brain and generates spontaneous seizures. Epileptogenesis is the process by which brain injury leads to chronic epilepsy. Epileptogenesis can be triggered by both acquired as well as genetic factors. Previously, epileptogenesis was considered to be represented by the latent period, but recently, based on clinical observations, epileptogenesis is now considered to extend beyond the latent period. The procedure of epileptogenesis typically happens in three phases: first, the occurrence event, second, a ‘latent’ period and third, chronic conventional epilepsy. In recent studies, it has been finding out that mTOR and REST pathways are responsible for temporal lobe epileptogenesis. The original mechanisms of epileptogenesis are debatable. There is not a singular mechanism that applies to all epilepsy syndromes. It can be brought by an “epilepsy gene”, long-lasting neurodegenerative illnesses, or different kinds of acute brain insults. Brain pathologies that are associated with Epileptogenesis are microgliosis, astrocytosis, neuronal cell death; chronic axonal changes, etc. Epileptogenesis refers to the expansion of tissue that causes repeated unprovoked seizures leading to the development of an epileptic situation. The frequency of seizures and epilepsies is comparatively more throughout the neonatal and infantile periods. Certain conditions, like cell loss due to seizure, and metabolic and genetic changes, lead to epileptogenesis. Epileptogenesis is also the development of epileptic indications in some forms of epilepsy after the preliminary seizures occur. To prevent epilepsy, studies are aimed to identify the important neuronal mechanisms of epileptogenesis in diverse types of epilepsy. Then the abort or reverse of the procedure is denoted as antiepileptogenesis. Antiepileptogenesis can lead to complete prevention which stops the development of epilepsy. It can also prevent partially which delays in the progress of epilepsy or lessens its severity.