EIF2B

http://dbpedia.org/resource/EIF2B an entity of type: Abstraction100002137

eIF2B is a protein complex found in eukaryotes. It is the guanine nucleotide exchange factor for the eukaryotic initiation factor 2 and therefore converts the inactive eIF2-GDP to the active eIF2-GTP. This activation is hindered by phosphorylation of the alpha subunit of eIF2, which leads to a stable eIF2α-P-GDP-eIF2B complex and therefore inhibits translation initiation. Human genes which encode eIF-2B proteins include: * EIF2B1 – alpha subunit (26kDa) * EIF2B2 – beta subunit (39kDa) * EIF2B3 – gamma subunit (58kDa) * EIF2B4 – delta subunit (67kDa) * EIF2B5 – epsilon subunit (82kDa) rdf:langString
eIF2B(eukaryotic initiation factor 2B,真核起始因子2B)是一种参与真核翻译起始的重要的蛋白质,也是一种。其作用是在翻译起始过程中,将eIF2上结合的GDP(eIF2·GDP,eIF2的非活性状态)转换为GTP(eIF2·GTP,eIF2的活性状态),使得eIF2可以重新参与翻译起始。因此,在细胞中,eIF2B的作用是使足量的eIF2·GTP存在以参与翻译起始过程。 eIF2B是一种多亚基复合物,包含五个亚基,分别为α、β、γ、δ和ε。 eIF2B是与细胞生存紧密相关的真核起始因子。最近的一些研究表明,一种严重的遗传性神经退行性疾病——“”,就是由于eIF2B的两个不同亚基的编码基因的突变引起的。 rdf:langString
rdf:langString EIF2B
rdf:langString EIF2B
xsd:integer 19536634
xsd:integer 1002391194
rdf:langString eIF2B is a protein complex found in eukaryotes. It is the guanine nucleotide exchange factor for the eukaryotic initiation factor 2 and therefore converts the inactive eIF2-GDP to the active eIF2-GTP. This activation is hindered by phosphorylation of the alpha subunit of eIF2, which leads to a stable eIF2α-P-GDP-eIF2B complex and therefore inhibits translation initiation. Human genes which encode eIF-2B proteins include: * EIF2B1 – alpha subunit (26kDa) * EIF2B2 – beta subunit (39kDa) * EIF2B3 – gamma subunit (58kDa) * EIF2B4 – delta subunit (67kDa) * EIF2B5 – epsilon subunit (82kDa)
rdf:langString eIF2B(eukaryotic initiation factor 2B,真核起始因子2B)是一种参与真核翻译起始的重要的蛋白质,也是一种。其作用是在翻译起始过程中,将eIF2上结合的GDP(eIF2·GDP,eIF2的非活性状态)转换为GTP(eIF2·GTP,eIF2的活性状态),使得eIF2可以重新参与翻译起始。因此,在细胞中,eIF2B的作用是使足量的eIF2·GTP存在以参与翻译起始过程。 eIF2B是一种多亚基复合物,包含五个亚基,分别为α、β、γ、δ和ε。 eIF2B是与细胞生存紧密相关的真核起始因子。最近的一些研究表明,一种严重的遗传性神经退行性疾病——“”,就是由于eIF2B的两个不同亚基的编码基因的突变引起的。
xsd:nonNegativeInteger 1185

data from the linked data cloud