Dihydroxyphenylglycine
http://dbpedia.org/resource/Dihydroxyphenylglycine an entity of type: Thing
(S)-3,5-Dihydroxyphenylglycine or DHPG is a potent agonist of group I metabotropic glutamate receptors (mGluRs) mGluR1 and mGluR5. DHPG was the first agonist shown to be selective for group I mGluRs. Agonist activity is found in only the (S)-isomer, and (S)-DHPG may be a partial agonist of group I mGluRs. (S)-DHPG has been investigated for therapeutic effects in the treatment of neuronal injury (such as those associated with ischemia or hypoxia), cognitive enhancement, and Alzheimer's disease. 3,5-Dihydroxyphenylglycine can be isolated from the latex of Euphorbia helioscopia.
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Dihydroxyphenylglycine
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Dihydroxyphenylglycine.png
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(S)-3,5-Dihydroxyphenylglycine or DHPG is a potent agonist of group I metabotropic glutamate receptors (mGluRs) mGluR1 and mGluR5. DHPG was the first agonist shown to be selective for group I mGluRs. Agonist activity is found in only the (S)-isomer, and (S)-DHPG may be a partial agonist of group I mGluRs. (S)-DHPG has been investigated for therapeutic effects in the treatment of neuronal injury (such as those associated with ischemia or hypoxia), cognitive enhancement, and Alzheimer's disease. 3,5-Dihydroxyphenylglycine can be isolated from the latex of Euphorbia helioscopia. DHGP is also found in vancomycin and related glycopeptides. Although the (S) stereoisomer is synthesized by the DpgA-D enzymes, it is the (R) stereoisomer that is used in vancomycin and other related compounds. DHPG is enzymatically derived from the polyketide synthase pathway.
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6136
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3,5-dihydroxyphenylglycine, DHPG, S-DHPG
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(S)-2-amino-2-(3,5-dihydroxyphenyl)acetic acid
