Diclofensine
http://dbpedia.org/resource/Diclofensine an entity of type: Thing
Diclofensine (Ro 8-4650) was developed by Hoffmann-La Roche in the 1970s in the search for a new antidepressant. It was found that the (S)-isomer was responsible for activity. Is a stimulant drug which acts as a triple monoamine reuptake inhibitor, primarily inhibiting the reuptake of dopamine and norepinephrine, with affinities (Ki) of 16.8 nM, 15.7 nM, and 51 nM for DAT, NET, and SERT (dopamine, norepinephrine and serotonin transporters), respectively. It was found to be an effective antidepressant in human trials, with relatively few side effects, but was ultimately dropped from clinical development, possibly due to concerns about its abuse potential.
rdf:langString
rdf:langString
Diclofensine
xsd:integer
17710080
xsd:integer
1118734190
rdf:langString
None
xsd:integer
17
xsd:integer
67165
xsd:integer
287257
xsd:integer
62103
xsd:integer
2
xsd:integer
17
xsd:integer
4
rdf:langString
Legal
xsd:integer
1
xsd:integer
1
xsd:integer
68871
rdf:langString
CN1CCC3=CCCl
xsd:integer
1
rdf:langString
ZJDCGVDEEHWEIG-UHFFFAOYSA-N
xsd:integer
9
rdf:langString
changed
xsd:integer
443772595
rdf:langString
changed
rdf:langString
Diclofensine (Ro 8-4650) was developed by Hoffmann-La Roche in the 1970s in the search for a new antidepressant. It was found that the (S)-isomer was responsible for activity. Is a stimulant drug which acts as a triple monoamine reuptake inhibitor, primarily inhibiting the reuptake of dopamine and norepinephrine, with affinities (Ki) of 16.8 nM, 15.7 nM, and 51 nM for DAT, NET, and SERT (dopamine, norepinephrine and serotonin transporters), respectively. It was found to be an effective antidepressant in human trials, with relatively few side effects, but was ultimately dropped from clinical development, possibly due to concerns about its abuse potential. Diclofensine is chemically a tetrahydroisoquinoline (THIQ) derivative, as is nomifensine.
xsd:nonNegativeInteger
8421
xsd:string
67165-56-4
xsd:string
287257
xsd:string
xsd:string
09HKW863J6
xsd:string
68871
