DPA-714
http://dbpedia.org/resource/DPA-714 an entity of type: Thing
DPA-714 or N,N-diethyl-2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-acetamide is a selective ligand for the translocator protein (TSPO) currently under evaluation for several clinical applications. For this reason, a practical, multigram synthetic route for its preparation has been described. The binding affinity of DPA-714 for TSPO is reported as Ki = 7.0 ± 0.4 nM.
rdf:langString
rdf:langString
DPA-714
xsd:integer
36064475
xsd:integer
1002398061
xsd:integer
22
xsd:integer
958233
xsd:integer
512306
xsd:integer
23328478
xsd:integer
1
xsd:integer
27
rdf:langString
N,N-diethyl-2-[4-phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-acetamide
xsd:integer
4
xsd:integer
2
rdf:langString
CCNCCc1cc3cccOCCF
xsd:integer
1
rdf:langString
FLZZFWBNYJNHMY-UHFFFAOYSA-N
rdf:langString
Y1H4D2VKZD
rdf:langString
DPA-714 or N,N-diethyl-2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-acetamide is a selective ligand for the translocator protein (TSPO) currently under evaluation for several clinical applications. For this reason, a practical, multigram synthetic route for its preparation has been described. The binding affinity of DPA-714 for TSPO is reported as Ki = 7.0 ± 0.4 nM. [18F]DPA-714 is currently under investigation as a potential radiopharmaceutical for imaging TSPO in living systems using positron emission tomography (PET). DPA-714, along with other members of the DPA class of TSPO ligands, has been shown to decrease microglial activation and increase neuronal survival in a quinolinic acid rat model of excitotoxic neurodegeneration, suggesting potential neuroprotective effects.
xsd:nonNegativeInteger
4828
xsd:string
958233-07-3
xsd:string
512306
xsd:string
Y1H4D2VKZD