DNA replication stress
http://dbpedia.org/resource/DNA_replication_stress
DNA replication stress refers to the state of a cell whose genome is exposed to various stresses. The events that contribute to replication stress occur during DNA replication, and can result in a stalled replication fork. There are many events that contribute to replication stress, including:
* Misincorporation of ribonucleotides
* Unusual DNA structures
* Conflicts between replication and transcription
* Insufficiency of essential replication factors
* Common fragile sites
* Overexpression or constitutive activation of oncogenes
* Chromatin inaccessibility
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DNA replication stress
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DNA replication stress refers to the state of a cell whose genome is exposed to various stresses. The events that contribute to replication stress occur during DNA replication, and can result in a stalled replication fork. There are many events that contribute to replication stress, including:
* Misincorporation of ribonucleotides
* Unusual DNA structures
* Conflicts between replication and transcription
* Insufficiency of essential replication factors
* Common fragile sites
* Overexpression or constitutive activation of oncogenes
* Chromatin inaccessibility ATM and ATR are proteins that help to alleviate replication stress. Specifically, they are kinases that are recruited and activated by DNA damage. The stalled replication fork can collapse if these regulatory proteins fail to stabilize it. When this occurs, reassembly of the fork is initiated in order to repair the damaged DNA end.
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