Cytochrome P450 aromatic O-demethylase
http://dbpedia.org/resource/Cytochrome_P450_aromatic_O-demethylase
Cytochrome P450 aromatic O-demethylase is a bacterial enzyme that catalyzes the demethylation of lignin and various lignols. The net reaction follows the following stoichiometry, illustrated with a generic methoxy arene: ArOCH3 + O2 + 2 e− + 2 H+ → ArOH + CH2O + H2O The enzyme is notable for its promiscuity, it effects the O-demethylation of a range of substrates, including lignin.
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Cytochrome P450 aromatic O-demethylase
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Aromatic O-demethylase, cytochrome P450 subunit
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Aromatic O-demethylase, reductase subunit
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63122178
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1110745557
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Crystal structure of gcoB complexed with FAD and an iron–sulfur cluster based on .
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Crystal structure of gcoA in complex with heme and guaiacol based on .
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1.14
1.6
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Amycolatopsis sp.
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gcoA
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gcoB
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385957
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P0DPQ7
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P0DPQ8
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Cytochrome P450 aromatic O-demethylase is a bacterial enzyme that catalyzes the demethylation of lignin and various lignols. The net reaction follows the following stoichiometry, illustrated with a generic methoxy arene: ArOCH3 + O2 + 2 e− + 2 H+ → ArOH + CH2O + H2O The enzyme is notable for its promiscuity, it effects the O-demethylation of a range of substrates, including lignin. It is a heterodimeric protein derived from the products of two genes. The component proteins are a cytochrome P450 enzyme (encoded by the gcoA gene from the family CYP255A) and a three-domain reductase (encoded by the gcoB gene) complexed with three cofactors (2Fe-2S, FAD, and NADH).
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5
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8513
