Cold agglutinin disease

http://dbpedia.org/resource/Cold_agglutinin_disease an entity of type: Thing

داء الراصات الباردة هو مرض مناعة ذاتية يتصف بوجود تركيزاتٍ عالية من الأجسام المضادة الدوارة عادةً ما تكون كريين مناعي م (IgM) موجه ضد خلايا الدم الحمراء. وهو على وجه الخصوص شكلٌ من أشكال فقر الدم الانحلالي بالمناعة الذاتية، تربط فيه الأجسام المضادة خلايا الدم الحمراء فقط في درجات حرارة الجسم المنخفضة التي تتراوح غالبًا ما بين 28-31 درجة حرارة مئوية. وقد تم وصفه لأول مرة في عام 1957، rdf:langString

La maladie des agglutinines froides est une maladie auto-immune caractérisée par une forte concentration d'anticorps circulant, le plus souvent des IgM, dirigées contre les érythrocytes. C'est une forme d'anémie hémolytique auto-immune, plus précisément de celles où les anticorps lient uniquement les hématies entre elles à basse température, généralement entre 28 et 31 °C. Elle a été décrite pour la première fois en 1957. rdf:langString

La sindrome da agglutinine a frigore, o malattia da agglutinine fredde, si manifesta come una malattia immunologica con caratteristiche presenze di autoanticorpi IgM che agglutinano in modo ottimale i globuli rossi a temperature molto basse, intorno ai 4 °C, definite crioagglutinine o "agglutinine fredde". Le crioagglutinine policlonali aumentano dopo che l'individuo viene assoggettato ad alcune infezioni, come micoplasmi, tripanosmiasi e malaria che raggiungono il loro limite in 2-3 settimane ma non sono significative se non mostrano segni emolitici. rdf:langString

Köldagglutininsjukdom är en autoimmun sjukdom som karaktäriseras av höga koncentrationer av cirkulerande antikroppar, vanligtvis av IgM-typ, som går på erytrocyterna (röda blodkroppar). Det finns två typer av köldagglutininsjukdom: * Primär köldagglutininsjukdom: okänt ursprung . * Sekundär köldagglutininsjukdom orsakat av: * Lymfoproliferativa sjukdomar hos vuxna, såsom lymfom och kronisk lymfatisk leukemi, eller infektion. * Infektion associerad med sjukdomar såsom HIV, mukoplasmapneumoni eller mononukleos. rdf:langString

Cold agglutinin disease (CAD) is a rare autoimmune disease characterized by the presence of high concentrations of circulating cold sensitive antibodies, usually IgM and autoantibodies that are also active at temperatures below 30 °C (86 °F), directed against red blood cells, causing them to agglutinate and undergo lysis. It is a form of autoimmune hemolytic anemia, specifically one in which antibodies bind red blood cells only at low body temperatures, typically 28–31 °C. Cold agglutinin disease was first described in 1957. rdf:langString

rdfs:label

rdf:langString Cold agglutinin disease

rdf:langString داء الراصات الباردة

rdf:langString Maladie des agglutinines froides

rdf:langString Sindrome cronica da agglutinine a frigore

rdf:langString Köldagglutininsjukdom

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rdf:langString Cold agglutinin disease

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rdf:langString Cold agglutinin disease

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rdf:langString Cold agglutination - at body temperature, the antibodies do not attach to the red blood cells. At lower temperatures, however, the antibodies react to Ii antigens, bringing the red blood cells together, a process known as agglutination

dbpedia-owl:abstract

rdf:langString داء الراصات الباردة هو مرض مناعة ذاتية يتصف بوجود تركيزاتٍ عالية من الأجسام المضادة الدوارة عادةً ما تكون كريين مناعي م (IgM) موجه ضد خلايا الدم الحمراء. وهو على وجه الخصوص شكلٌ من أشكال فقر الدم الانحلالي بالمناعة الذاتية، تربط فيه الأجسام المضادة خلايا الدم الحمراء فقط في درجات حرارة الجسم المنخفضة التي تتراوح غالبًا ما بين 28-31 درجة حرارة مئوية. وقد تم وصفه لأول مرة في عام 1957،

rdf:langString Cold agglutinin disease (CAD) is a rare autoimmune disease characterized by the presence of high concentrations of circulating cold sensitive antibodies, usually IgM and autoantibodies that are also active at temperatures below 30 °C (86 °F), directed against red blood cells, causing them to agglutinate and undergo lysis. It is a form of autoimmune hemolytic anemia, specifically one in which antibodies bind red blood cells only at low body temperatures, typically 28–31 °C. When affected people's blood is exposed to cold temperatures (32 °F (0 °C; 273 K) to 50 °F (10 °C; 283 K)), certain proteins that normally attack bacteria (IgM antibodies) attach themselves to red blood cells and bind them together into clumps (agglutination). This eventually causes red blood cells to be prematurely destroyed (hemolysis) leading to anemia and other associated signs and symptoms. Cold agglutinin disease can be primary (unknown cause) or secondary, due to an underlying condition such as an infection, another autoimmune disease, or certain cancers. Treatment depends on many factors including the severity of the condition, the signs and symptoms present in each person, and the underlying cause. Cold agglutinin disease was first described in 1957.

rdf:langString La maladie des agglutinines froides est une maladie auto-immune caractérisée par une forte concentration d'anticorps circulant, le plus souvent des IgM, dirigées contre les érythrocytes. C'est une forme d'anémie hémolytique auto-immune, plus précisément de celles où les anticorps lient uniquement les hématies entre elles à basse température, généralement entre 28 et 31 °C. Elle a été décrite pour la première fois en 1957.

rdf:langString La sindrome da agglutinine a frigore, o malattia da agglutinine fredde, si manifesta come una malattia immunologica con caratteristiche presenze di autoanticorpi IgM che agglutinano in modo ottimale i globuli rossi a temperature molto basse, intorno ai 4 °C, definite crioagglutinine o "agglutinine fredde". Le crioagglutinine policlonali aumentano dopo che l'individuo viene assoggettato ad alcune infezioni, come micoplasmi, tripanosmiasi e malaria che raggiungono il loro limite in 2-3 settimane ma non sono significative se non mostrano segni emolitici.

rdf:langString Köldagglutininsjukdom är en autoimmun sjukdom som karaktäriseras av höga koncentrationer av cirkulerande antikroppar, vanligtvis av IgM-typ, som går på erytrocyterna (röda blodkroppar). Det finns två typer av köldagglutininsjukdom: * Primär köldagglutininsjukdom: okänt ursprung . * Sekundär köldagglutininsjukdom orsakat av: * Lymfoproliferativa sjukdomar hos vuxna, såsom lymfom och kronisk lymfatisk leukemi, eller infektion. * Infektion associerad med sjukdomar såsom HIV, mukoplasmapneumoni eller mononukleos.

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