Cdc6
http://dbpedia.org/resource/Cdc6 an entity of type: Thing
Cdc6, or cell division cycle 6, is a protein in eukaryotic cells. It is mainly studied in the budding yeast Saccharomyces cerevisiae (P09119). It is an essential regulator of DNA replication and plays important roles in the activation and maintenance of the checkpoint mechanisms in the cell cycle that coordinate S phase and mitosis. It is part of the pre-replicative complex (pre-RC) and is required for loading minichromosome maintenance (MCM) proteins onto the DNA, an essential step in the initiation of DNA synthesis. In addition, it is a member of the family of AAA+ ATPases and highly related to ORC1; both are the same protein in archaea.
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El Cdc6 es un regulador esencial de la replicación del ADN y juega un papel importante en la activación y el mantenimiento de los mecanismos de control en el ciclo celular que coordinan la fase S y la mitosis. Es parte del complejo pre-replicativo (pre-RC) y es necesario para la carga de mantenimiento de cromosomas Mini (MCM) las proteínas en el ADN, un paso esencial en la iniciación de la síntesis de ADN. Además, es miembro de la familia de la AAA + ATPasas y altamente asociado con el Orc1p.
* Datos: Q5055656
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Cdc6
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Cdc6
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Cdc6/Orc1, C-terminal
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Cell division protein Cdc6/18
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Orc1/Cdc6-type DNA replication protein, archaea
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19658026
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1108422658
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Crystal Structure of CDC6 from P. aerophilum . Green and blue domains are AAA domains; red domain is the Cdc6 C-terminal HTH domain .
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IPR014277
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IPR015163
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IPR016314
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PF09079
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Cdc6
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Cdc6_C
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Orc1/Cdc6_arc
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125
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Cdc6, or cell division cycle 6, is a protein in eukaryotic cells. It is mainly studied in the budding yeast Saccharomyces cerevisiae (P09119). It is an essential regulator of DNA replication and plays important roles in the activation and maintenance of the checkpoint mechanisms in the cell cycle that coordinate S phase and mitosis. It is part of the pre-replicative complex (pre-RC) and is required for loading minichromosome maintenance (MCM) proteins onto the DNA, an essential step in the initiation of DNA synthesis. In addition, it is a member of the family of AAA+ ATPases and highly related to ORC1; both are the same protein in archaea.
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El Cdc6 es un regulador esencial de la replicación del ADN y juega un papel importante en la activación y el mantenimiento de los mecanismos de control en el ciclo celular que coordinan la fase S y la mitosis. Es parte del complejo pre-replicativo (pre-RC) y es necesario para la carga de mantenimiento de cromosomas Mini (MCM) las proteínas en el ADN, un paso esencial en la iniciación de la síntesis de ADN. Además, es miembro de la familia de la AAA + ATPasas y altamente asociado con el Orc1p.
* Datos: Q5055656
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cd08768
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10716
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Cdc6
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Cdc6_C
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Orc1/Cdc6_arc
