Carbamoyl phosphate synthetase
http://dbpedia.org/resource/Carbamoyl_phosphate_synthetase an entity of type: Thing
Karbamoylfosfatsyntas är ett enzym som katalyserar bildandet av från glutamin eller frånt ATP, koldioxid och ammoniak. Enzymet deltar i argininbiosyntesen och ureacykeln. Det finns tre olika isoenyzymer, varav två återfinns hos människa:
* Karbamoylfosfatsyntas I - mitokondriellt enzym som deltar i ureacykeln.
* Karbamoylfosfatsyntas II - cytosoliskt enzym som deltar i metabolismen av pyrimidiner, där det har reglerande funktion.
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氨甲酰磷酸合成酶（英語：Carbamoyl phosphate synthetase）是催化自穀氨醯胺（EC 6.3.5.5）或氨（EC 6.3.4.16）与碳酸氢盐合成这一反应的一种ATP依赖性酶。此酶催化ATP与碳酸氢盐产生了氨甲酰磷酸与ADP。羰基磷酸盐先与氨反应产生。接下来，氨基甲酸盐与第二分子的ATP反应生成与ADP。 在原核生物与真核生物中，氨甲酰磷酸合成酶催化了嘧啶与精氨酸的生物合成以及大多数陆栖脊椎动物尿素循环中的首个关键步骤。大多数原核生物都只有一种类型氨甲酰磷酸合成酶，后者同时用于精氨酸与嘧啶的生物合成，然而某些细菌有着分别不同的类型。 此酶有三种不同型，供应各不相同的功能。
* （线粒体酶，尿素循环）
* （胞质溶胶酶，嘧啶代谢）
* （存在于鱼类之中）。
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Carbamoyl phosphate synthetase catalyzes the ATP-dependent synthesisof carbamoyl phosphate from glutamine (EC 6.3.5.5) or ammonia (EC 6.3.4.16) and bicarbonate. This enzyme catalyzes the reaction of ATP and bicarbonate to produce carboxy phosphate and ADP. Carboxy phosphate reacts with ammonia to give carbamic acid. In turn, carbamic acid reacts with a second ATP to give carbamoyl phosphate plus ADP. There are three different forms that serve very different functions:
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Fosfato de carbamoílo sintase (abreviada na literatura em inglês CPSase, carbamoyl phosphate synthetase) catalisa a síntese dependente de ATP de fosfato de carbamoílo a partir da glutamina (EC 6.3.5.5) ou amônia (EC 6.3.4.16) e bicarbonato. Esta enzima catalisa a reação de ATP e bicarbonato para produzir carboxifosfato e ADP. Carboxifosfato reage com amônia resultando em ácido carbâmico. Por sua vez, o ácido carbâmico reage com um segundo ATP resultando em carbamilfosfato mais ADP.
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Carbamoyl phosphate synthetase
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Fosfato de carbamoílo sintase
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Karbamoylfosfatsyntas
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氨甲酰磷酸合成酶
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Carbamoyl phosphate synthetase (ammonia)
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CPSase large subunit ATP-binding domain
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CPSase large subunit N-terminal domain
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CPSase large subunit oligomerisation domain
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CPSase small subunit N-terminal domain
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Carbamoyl phosphate synthetase
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11274275
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1097059506
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PDOC00676
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1
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inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin
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structure of carbamoyl phosphate synthetase complexed with the atp analog amppnp
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the structure of biotin carboxylase, mutant e288k, complexed with atp
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crystal structure of the biotin carboxylase subunit of pyruvate carboxylase
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37318
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6.3
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IPR002474
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IPR005479
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IPR005480
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IPR005481
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6
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PF00289
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PF00988
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PF02786
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PF02787
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CL0179
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CPSase_L_D2
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CPSase_L_D3
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CPSase_L_chain
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CPSase_sm_chain
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Carbamoyl phosphate synthetase catalyzes the ATP-dependent synthesisof carbamoyl phosphate from glutamine (EC 6.3.5.5) or ammonia (EC 6.3.4.16) and bicarbonate. This enzyme catalyzes the reaction of ATP and bicarbonate to produce carboxy phosphate and ADP. Carboxy phosphate reacts with ammonia to give carbamic acid. In turn, carbamic acid reacts with a second ATP to give carbamoyl phosphate plus ADP. It represents the first committed step in pyrimidine and arginine biosynthesis in prokaryotes and eukaryotes, and in the urea cycle in most terrestrial vertebrates. Most prokaryotes carry one form of CPSase that participates in both arginine and pyrimidine biosynthesis, however certain bacteria can have separate forms. There are three different forms that serve very different functions:
* Carbamoyl phosphate synthetase I (mitochondria, urea cycle)
* Carbamoyl phosphate synthetase II (cytosol, pyrimidine metabolism).
* Carbamoyl phosphate synthetase III (found in fish).
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Karbamoylfosfatsyntas är ett enzym som katalyserar bildandet av från glutamin eller frånt ATP, koldioxid och ammoniak. Enzymet deltar i argininbiosyntesen och ureacykeln. Det finns tre olika isoenyzymer, varav två återfinns hos människa:
* Karbamoylfosfatsyntas I - mitokondriellt enzym som deltar i ureacykeln.
* Karbamoylfosfatsyntas II - cytosoliskt enzym som deltar i metabolismen av pyrimidiner, där det har reglerande funktion.
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Fosfato de carbamoílo sintase (abreviada na literatura em inglês CPSase, carbamoyl phosphate synthetase) catalisa a síntese dependente de ATP de fosfato de carbamoílo a partir da glutamina (EC 6.3.5.5) ou amônia (EC 6.3.4.16) e bicarbonato. Esta enzima catalisa a reação de ATP e bicarbonato para produzir carboxifosfato e ADP. Carboxifosfato reage com amônia resultando em ácido carbâmico. Por sua vez, o ácido carbâmico reage com um segundo ATP resultando em carbamilfosfato mais ADP. Representa o primeiro passo comprometido na biossíntese de pirimidina e arginina em procariontes e eucariotas, e no ciclo da ureia na maioria dos vertebrados terrestres. A maioria dos procariontes porta uma forma de CPSase participa em ambas as biossínteses de arginina e pirimidina, entretanto certas bactérias podem apresentar formas distintas.
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氨甲酰磷酸合成酶（英語：Carbamoyl phosphate synthetase）是催化自穀氨醯胺（EC 6.3.5.5）或氨（EC 6.3.4.16）与碳酸氢盐合成这一反应的一种ATP依赖性酶。此酶催化ATP与碳酸氢盐产生了氨甲酰磷酸与ADP。羰基磷酸盐先与氨反应产生。接下来，氨基甲酸盐与第二分子的ATP反应生成与ADP。 在原核生物与真核生物中，氨甲酰磷酸合成酶催化了嘧啶与精氨酸的生物合成以及大多数陆栖脊椎动物尿素循环中的首个关键步骤。大多数原核生物都只有一种类型氨甲酰磷酸合成酶，后者同时用于精氨酸与嘧啶的生物合成，然而某些细菌有着分别不同的类型。 此酶有三种不同型，供应各不相同的功能。
* （线粒体酶，尿素循环）
* （胞质溶胶酶，嘧啶代谢）
* （存在于鱼类之中）。
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9622
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6.3.4.16
