Brilacidin
http://dbpedia.org/resource/Brilacidin an entity of type: Thing
Brilacidin (formerly PMX-30063), an investigational new drug (IND), is a polymer-based antibiotic currently in human clinical trials, and represents a new class of antibiotics called host defense protein mimetics, or HDP-mimetics, which are non-peptide synthetic small molecules modeled after host defense peptides (HDPs). HDPs, also called antimicrobial peptides, some of which are defensins, are part of the innate immune response and are common to most higher forms of life. As brilacidin is modeled after a defensin, it is also called a defensin mimetic.
rdf:langString
rdf:langString
Brilacidin
xsd:integer
40308088
xsd:integer
1084693494
rdf:langString
none
xsd:integer
40
xsd:integer
1224095
xsd:integer
2219413
xsd:integer
28651526
xsd:integer
6
xsd:integer
50
rdf:langString
N,N'-bis[3-{[5-pentanoyl]amino}-2-[-pyrrolidin-3-yloxy]-5-phenyl]pyrimidine-4,6-dicarboxamide
rdf:langString
D10414
xsd:integer
14
xsd:integer
6
xsd:integer
25023695
rdf:langString
C1CNC[C@@H]1OC2=CNCCCCCNCN
xsd:integer
1
rdf:langString
QPDYBCZNGUJZDK-DNQXCXABSA-N
rdf:langString
None as of July 2012
rdf:langString
I1679X069H
xsd:integer
300
rdf:langString
Brilacidin (formerly PMX-30063), an investigational new drug (IND), is a polymer-based antibiotic currently in human clinical trials, and represents a new class of antibiotics called host defense protein mimetics, or HDP-mimetics, which are non-peptide synthetic small molecules modeled after host defense peptides (HDPs). HDPs, also called antimicrobial peptides, some of which are defensins, are part of the innate immune response and are common to most higher forms of life. As brilacidin is modeled after a defensin, it is also called a defensin mimetic. Brilacidin is an antibiotic that works by disrupting bacterial cell membranes, mimicking defensins that play a role in innate immunity. Several mimics of antimicrobial peptides, both peptides and non-peptides, have been studied, but none have overcome difficulties to reach the market.
xsd:nonNegativeInteger
27001
rdf:langString
None as of July 2012
xsd:string
1224095-98-0
xsd:string
2219413
xsd:string
I1679X069H
xsd:string
D10414
xsd:string
25023695