BOP reagent
http://dbpedia.org/resource/BOP_reagent an entity of type: Thing
Das BOP-Reagenz ist ein Kupplungsreagenz, das früher in der Peptidsynthese verwendet wurde. Da die Reaktion mit BOP das Karzinogen HMPA freisetzt, wird stattdessen zunehmend PyBOP eingesetzt.
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Reagen BOP merupakan reagen yang umumnya digunakan dalam sintesis peptida. Penggunaannya tidak disarankan karena ia akan melepaskan HMPA yang bersifat karsinogen.
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BOP試薬（ぼっぷしやく、BOP reagent）とは、ホスホニウムを共通構造に持つ、ペプチド合成などに用いられる試薬である。 元はカストロ (Castro) らが開発したヘキサフルオロリン酸1H-ベンゾトリアゾール-1-イルオキシトリス（ジメチルアミノ）ホスホニウム（(Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; CAS番号56602-33-6; 略号BOP）を意味したが、今日では各種誘導体が開発されており、それらホスホニウム系ペプチド縮合剤を総称してBOP試薬と称する場合もある。
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BOP (benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate) reagent is a reagent commonly used in the synthesis of peptides. Its use is discouraged because coupling using BOP liberates HMPA which is carcinogenic, although for small scale use in an organic laboratory this is not a great disadvantage as it is in large scale industrial usage.BOP has been used for peptide coupling, synthesis of esters, esterification of carboxylic acids, or as a catalyst. This reagent is advantageous in peptide coupling to other derived reagents because there are no side reactions from the dehydration of asparagine or glutamine. In peptide coupling the BOP reagent works well because it forms reactive intermediates which allow for the amines to bond together with little energy loss. In the redu
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BOP-Reagenz
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BOP reagent
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Reagen BOP
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BOP試薬
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12649653
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1033131325
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BOP reagent.svg
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trisphosphonium hexafluorophosphate
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Castro's reagent
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408852615
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changed
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Das BOP-Reagenz ist ein Kupplungsreagenz, das früher in der Peptidsynthese verwendet wurde. Da die Reaktion mit BOP das Karzinogen HMPA freisetzt, wird stattdessen zunehmend PyBOP eingesetzt.
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BOP (benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate) reagent is a reagent commonly used in the synthesis of peptides. Its use is discouraged because coupling using BOP liberates HMPA which is carcinogenic, although for small scale use in an organic laboratory this is not a great disadvantage as it is in large scale industrial usage.BOP has been used for peptide coupling, synthesis of esters, esterification of carboxylic acids, or as a catalyst. This reagent is advantageous in peptide coupling to other derived reagents because there are no side reactions from the dehydration of asparagine or glutamine. In peptide coupling the BOP reagent works well because it forms reactive intermediates which allow for the amines to bond together with little energy loss. In the reduction of carboxylic acids, using the BOP reagent with NaBH4 resulted in high percent yields.
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Reagen BOP merupakan reagen yang umumnya digunakan dalam sintesis peptida. Penggunaannya tidak disarankan karena ia akan melepaskan HMPA yang bersifat karsinogen.
rdf:langString
BOP試薬（ぼっぷしやく、BOP reagent）とは、ホスホニウムを共通構造に持つ、ペプチド合成などに用いられる試薬である。 元はカストロ (Castro) らが開発したヘキサフルオロリン酸1H-ベンゾトリアゾール-1-イルオキシトリス（ジメチルアミノ）ホスホニウム（(Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; CAS番号56602-33-6; 略号BOP）を意味したが、今日では各種誘導体が開発されており、それらホスホニウム系ペプチド縮合剤を総称してBOP試薬と称する場合もある。
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3420
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Castro's reagent
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((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)