BD1060

http://dbpedia.org/resource/BD1060 an entity of type: Thing

BD1060 or N-[2-(3,4-dichlorophenyl)ethyl]-1-pyrrolidineethanamine is a selective sigma receptor antagonist, with a reported binding affinity of Ki = 3 ± 0.1 nM for the sigma-1 receptor and greater than 50 times selectivity over the sigma-2 receptor. Like other sigma receptor antagonists, pretreating Swiss Webster mice with BD1060 significantly reduces the behavioral toxicity of cocaine. rdf:langString

BD1060 o N-[2-(3,4-dichlorophenyl)ethyl]-1-pyrrolidineethanamine es un antagonista selecto del receptor sigma, con una afinidad de unión informada de Ki = 3 ± 0.1 nM por el receptor sigma-1 y superior a 50 veces selectividad sobre el receptor sigma-2. Al igual que otros antagonistas del receptor sigma, el tratamiento previo de ratones Swiss Webster con BD1060 reduce significativamente la toxicidad conductual de la cocaína. rdf:langString

rdfs:label

rdf:langString BD1060

dbpedia-owl:wikiPageID

xsd:integer 36175355

dbpedia-owl:wikiPageRevisionID

xsd:integer 992690827

dbpprop:c

xsd:integer 14

dbpprop:casNumber

xsd:integer 138356

dbpprop:chemspiderid

xsd:integer 8058042

dbpprop:cl

xsd:integer 2

dbpprop:h

xsd:integer 20

dbpprop:iupacName

rdf:langString N-[2-ethyl]-1-pyrrolidineethanamine

dbpprop:n

xsd:integer 2

dbpprop:pubchem

xsd:integer 9882367

dbpprop:smiles

rdf:langString C1CCNCCNCCC2=CCCl

dbpprop:stdinchi

xsd:integer 1

dbpprop:stdinchikey

rdf:langString KFLJZQLENAVFAL-UHFFFAOYSA-N

dbpedia-owl:abstract

rdf:langString BD1060 or N-[2-(3,4-dichlorophenyl)ethyl]-1-pyrrolidineethanamine is a selective sigma receptor antagonist, with a reported binding affinity of Ki = 3 ± 0.1 nM for the sigma-1 receptor and greater than 50 times selectivity over the sigma-2 receptor. Like other sigma receptor antagonists, pretreating Swiss Webster mice with BD1060 significantly reduces the behavioral toxicity of cocaine.

rdf:langString BD1060 o N-[2-(3,4-dichlorophenyl)ethyl]-1-pyrrolidineethanamine es un antagonista selecto del receptor sigma, con una afinidad de unión informada de Ki = 3 ± 0.1 nM por el receptor sigma-1 y superior a 50 veces selectividad sobre el receptor sigma-2. Al igual que otros antagonistas del receptor sigma, el tratamiento previo de ratones Swiss Webster con BD1060 reduce significativamente la toxicidad conductual de la cocaína.

dbpedia-owl:wikiPageLength

xsd:nonNegativeInteger 2351

dbpedia-owl:casNumber

xsd:string 138356-10-2

dbpedia-owl:pubchem

xsd:string 9882367

rdf:type

owl:Thing

<http://www.ontologydesignpatterns.org/ont/dul/DUL.owl#ChemicalObject>

dbpedia-owl:ChemicalSubstance

<http://www.wikidata.org/entity/Q8386>

yago:WikicatMolecularFormulas