Anthony John Clark

rdf:langString Anthony John Clark

rdf:langString Anthony John Clark OBE FRSE (18 September 1951 – 12 August 2004) was an English molecular biologist who was a founder of applying molecular technology to farm animals. He was director of the Roslin Institute from 2002 to 2004. His PhD was on Satellite DNA at the Medical Research Council Unit, in Edinburgh. From there he joined John Bishop's team at the Institute of Genetics, at the University of Edinburgh, where he carried out research into the genes in the liver of mice. In 1985 he was appointed to the Animal Breeding Research Organisation (subsequently the Roslin Institute) where he began work in genetic modification to produce a sheep giving milk with human proteins. He was successful within five years. Tracy, born in 1990, was the first sheep to produce large quantities of human protein, making 35g of the alpha-1-antitrypsin (used in treatment of cystic fibrosis) in each litre of her milk. During the 1990s, Clark continued to develop transgenic techniques on large animals. With his colleagues, he produced a sheep from which a prion protein gene had been removed, the first time this had been achieved in a large animal. Clark's work set the stage for Ian Wilmut's team at Roslin to clone a sheep, Dolly (1996), the result of transplanted DNA of an adult sheep to an unfertilized egg cell. He was appointed an OBE in 1997 for his contribution to Science.