Aminoglutethimide
http://dbpedia.org/resource/Aminoglutethimide an entity of type: Thing
أمينوغلوتيثيميد (بالإنجليزية: Aminoglutethimide) هو دواء يُستعمل في علاج:
* سرطان البروستاتا
* سرطان الثدي
* متلازمة كوشينغ
rdf:langString
L'aminoglutetimide è un farmaco ad azione anti-steroidea. È commercializzato da Novartis come Cytadren.
rdf:langString
Aminoglutetimida é um fármaco que inibe a esteroidogênese, sendo indicado para o tratamento da síndrome de Cushing reduzindo o nível do cortisol no organismo. Também é utilizadano tratamento do câncer ósseo doloroso, entre outras indicações. O princípio de ação farmacológico atua na inibição da conversão de colesterol em pregnenolona. Através desse mecanismo inibe a secreção de estrógeno, aldosterona e cortisol.
rdf:langString
Aminoglutetymid – organiczny związek chemiczny z grupy cyklicznych imidów. W organizmach żywych hamuje syntezę wszystkich hormonalnie czynnych steroidów. Aminoglutetymid jest inhibitorem aromatazy.
rdf:langString
Aminoglutethimide (AG), sold under the brand names Elipten, Cytadren, and Orimeten among others, is a medication which has been used in the treatment of seizures, Cushing's syndrome, breast cancer, and prostate cancer, among other indications. It has also been used by bodybuilders, athletes, and other men for muscle-building and performance- and physique-enhancing purposes. AG is taken by mouth three or four times per day.
rdf:langString
rdf:langString
أمينوغلوتيثيميد
rdf:langString
Aminoglutethimide
rdf:langString
Amminoglutetimide
rdf:langString
Aminoglutetymid
rdf:langString
Aminoglutetimida
xsd:integer
2984115
xsd:integer
1107484384
rdf:langString
BG01
rdf:langString
L02
rdf:langString
Rapid, complete
xsd:integer
13
xsd:integer
125
xsd:integer
31075
xsd:integer
2654
xsd:integer
488
xsd:integer
2060
rdf:langString
DB00357
<second>
45000.0
xsd:integer
16
rdf:langString
Aminoglutethimide molecule ball.png
xsd:integer
-3
rdf:langString
D00574
rdf:langString
a604039
rdf:langString
Liver
xsd:integer
2
xsd:integer
2
rdf:langString
D
xsd:integer
2145
rdf:langString
O=C1NCCCC1CC
xsd:integer
1
rdf:langString
ROBVIMPUHSLWNV-UHFFFAOYSA-N
rdf:langString
AG; AGI; Ba 16038; Ciba 16038; ND-1966; 2--2-ethylglutarimide
rdf:langString
Elipten, Cytadren, Orimeten, numerous others
xsd:integer
0
rdf:langString
verified
xsd:integer
456688404
rdf:langString
verified
xsd:integer
185
rdf:langString
أمينوغلوتيثيميد (بالإنجليزية: Aminoglutethimide) هو دواء يُستعمل في علاج:
* سرطان البروستاتا
* سرطان الثدي
* متلازمة كوشينغ
rdf:langString
Aminoglutethimide (AG), sold under the brand names Elipten, Cytadren, and Orimeten among others, is a medication which has been used in the treatment of seizures, Cushing's syndrome, breast cancer, and prostate cancer, among other indications. It has also been used by bodybuilders, athletes, and other men for muscle-building and performance- and physique-enhancing purposes. AG is taken by mouth three or four times per day. Side effects of AG include lethargy, somnolence, dizziness, headache, appetite loss, skin rash, hypertension, liver damage, and adrenal insufficiency, among others. AG is both an anticonvulsant and a steroidogenesis inhibitor. In terms of the latter property, it inhibits enzymes such as cholesterol side-chain cleavage enzyme (CYP11A1, P450scc) and aromatase (CYP19A1), thereby inhibiting the conversion of cholesterol into steroid hormones and blocking the production of androgens, estrogens, and glucocorticoids, among other endogenous steroids. As such, AG is an aromatase inhibitor and adrenal steroidogenesis inhibitor, including both an androgen synthesis inhibitor and a corticosteroid synthesis inhibitor. AG was introduced for medical use, as an anticonvulsant, in 1960. It was withdrawn in 1966 due to toxicity. Its steroidogenesis-inhibiting properties were discovered serendipitously and it was subsequently repurposed for use in the treatment of Cushing's syndrome, breast cancer, and prostate cancer from 1969 and thereafter. However, although used in the past, it has mostly been superseded by newer agents with better efficacy and lower toxicity such as ketoconazole, abiraterone acetate, and other aromatase inhibitors. It remains marketed only in a few countries.
rdf:langString
L'aminoglutetimide è un farmaco ad azione anti-steroidea. È commercializzato da Novartis come Cytadren.
rdf:langString
Aminoglutetimida é um fármaco que inibe a esteroidogênese, sendo indicado para o tratamento da síndrome de Cushing reduzindo o nível do cortisol no organismo. Também é utilizadano tratamento do câncer ósseo doloroso, entre outras indicações. O princípio de ação farmacológico atua na inibição da conversão de colesterol em pregnenolona. Através desse mecanismo inibe a secreção de estrógeno, aldosterona e cortisol.
rdf:langString
Aminoglutetymid – organiczny związek chemiczny z grupy cyklicznych imidów. W organizmach żywych hamuje syntezę wszystkich hormonalnie czynnych steroidów. Aminoglutetymid jest inhibitorem aromatazy.
xsd:integer
7054
rdf:langString
D
xsd:nonNegativeInteger
31312
rdf:langString
Elipten, Cytadren, Orimeten, numerous others
xsd:string
125-84-8
xsd:string
31075-85-1 (hydrochloride)
xsd:string
2654
xsd:string
488
xsd:string
DB00357
xsd:string
0O54ZQ14I9
xsd:string
D00574
xsd:string
a604039
xsd:string
2145