Altanserin
http://dbpedia.org/resource/Altanserin an entity of type: Thing
Altanserin is a compound that binds to the 5-HT2A receptor (5-Hydroxytryptamine (serotonin) 2A receptor). Labeled with the isotope fluorine-18 it is used as a radioligand in positron emission tomography (PET) studies of the brain, i.e., studies of the 5-HT2A neuroreceptors. Besides human neuroimaging studies altanserin has also been used in the study of rats. An alternative SPECT radioligand is the [123I]-5-I-R91150 receptor antagonist. A rapid chemical synthesis of fluorine-18 and H-2 dual-labeled altanserin has been described.
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Altanserin
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Altanserin is a compound that binds to the 5-HT2A receptor (5-Hydroxytryptamine (serotonin) 2A receptor). Labeled with the isotope fluorine-18 it is used as a radioligand in positron emission tomography (PET) studies of the brain, i.e., studies of the 5-HT2A neuroreceptors. Besides human neuroimaging studies altanserin has also been used in the study of rats. An alternative for PET imaging the 5-HT2A receptor is the [11C]volinanserin (MDL-100,907) radioligand.18F-altanserin and 3H-volinanserin have shown very comparable binding.Both altanserin and MDL 100,907 are 5-HT2A receptor antagonists.[18F]-setoperone can also be used in PET. An alternative SPECT radioligand is the [123I]-5-I-R91150 receptor antagonist. A rapid chemical synthesis of fluorine-18 and H-2 dual-labeled altanserin has been described. Other ligands for other parts of the serotonin system used in PET studies are, e.g., DASB, ketanserin, and WAY-100635.
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