ADAMTS

http://dbpedia.org/resource/ADAMTS an entity of type: Abstraction100002137

ADAMTS (« A And Metalloproteinase with Thrombospondin Motifs ») est une famille de protéines jouant un rôle de peptidases. Les membres de la famille sont : * * * * * (= ADAMTS11) * * ADAMTS7 * (ouMETH-2), un antiangiogène * * * * ADAMTS13 * * * * * * * rdf:langString

ADAMTS ("ADAM-протеазы, содержащие мотив тромбоспондина") - семейство белков, осуществляющих множество функций в процессах морфогенеза тканей, патологического преобразования тканей, в процессах воспаления и в процессах построения сосудов. В организме человека по состоянию на 2021 год было обнаружено 19 белков семейства ADAMTS, которым присвоены индексы от 1 до 20 (номер 11 пропущен, т.к. было обнаружено, что этот же белок ранее получил индекс 5). rdf:langString

ADAMTS (short for a disintegrin and metalloproteinase with thrombospondin motifs) is a family of multidomain extracellular protease enzymes. 19 members of this family have been identified in humans, the first of which, ADAMTS1, was described in 1997. Known functions of the ADAMTS proteases include processing of procollagens and von Willebrand factor as well as cleavage of aggrecan, versican, brevican and neurocan, making them key remodeling enzymes of the extracellular matrix. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. Homologous subfamily of ADAMTSL (ADAMTS-like) proteins, which lack enzymatic activity, has also been described. Most cases of thrombotic thrombocytopenic purpur rdf:langString

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rdf:langString ADAMTS

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xsd:integer 15179824

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xsd:integer 1021389104

dbpedia-owl:abstract

rdf:langString ADAMTS (short for a disintegrin and metalloproteinase with thrombospondin motifs) is a family of multidomain extracellular protease enzymes. 19 members of this family have been identified in humans, the first of which, ADAMTS1, was described in 1997. Known functions of the ADAMTS proteases include processing of procollagens and von Willebrand factor as well as cleavage of aggrecan, versican, brevican and neurocan, making them key remodeling enzymes of the extracellular matrix. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. Homologous subfamily of ADAMTSL (ADAMTS-like) proteins, which lack enzymatic activity, has also been described. Most cases of thrombotic thrombocytopenic purpura arise from autoantibody-mediated inhibition of ADAMTS13. Like ADAMs, the name of the ADAMTS family refers to its disintegrin and metalloproteinase activity, and in the case of ADAMTS, the presence of a thrombospondin motif.

rdf:langString ADAMTS (« A And Metalloproteinase with Thrombospondin Motifs ») est une famille de protéines jouant un rôle de peptidases. Les membres de la famille sont : * * * * * (= ADAMTS11) * * ADAMTS7 * (ouMETH-2), un antiangiogène * * * * ADAMTS13 * * * * * * *

rdf:langString ADAMTS ("ADAM-протеазы, содержащие мотив тромбоспондина") - семейство белков, осуществляющих множество функций в процессах морфогенеза тканей, патологического преобразования тканей, в процессах воспаления и в процессах построения сосудов. В организме человека по состоянию на 2021 год было обнаружено 19 белков семейства ADAMTS, которым присвоены индексы от 1 до 20 (номер 11 пропущен, т.к. было обнаружено, что этот же белок ранее получил индекс 5).

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